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Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum
Liu, Boyan1,2; Cao, Lili1; Zhang, Lijun1,2; Yuan, Xiaofan1; Zhao, Bing1
2017
Source PublicationMOLECULES
ISSN1420-3049
Volume22Issue:1
AbstractEupatorium adenophorum is widely distributed throughout the world's tropical and temperate regions. It has become a harmful weed of crops and natural environments. Its leaves contain bioactive compounds such as chlorogenic acid and may be used as feed additives. In this study, chlorogenic acid was extracted and separated from leaves of E. adenophorum. Three chlorogenic acid products were prepared with different purities of 6.11%, 22.17%, and 96.03%. Phytochemical analysis demonstrated that the main toxins of sesquiterpenes were almost completely removed in sample preparation procedure. The three products were evaluated for safety via in vitro and in vivo toxicological studies. All the products exhibited no cytotoxic effects at a dose of 400 mu g/mL in an in vitro cell viability assay. When administered in vivo at a single dose up to 1.5 g/kg bw, all three products caused no signs or symptoms of toxicity in mice. These results encourage further exploration of extracts from E. adenophorum in feed additive application.
KeywordEupatorium Adenophorum Chlorogenic Acid Sesquiterpenes Safety Toxicity
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3390/molecules22010067
Indexed BySCI
Language英语
WOS KeywordIN-VITRO ; AGERATINA-ADENOPHORA ; COUNTERCURRENT CHROMATOGRAPHY ; ESSENTIAL OILS ; CAFFEIC ACID ; HEPG2 CELLS ; SEPARATION ; HEPATOTOXICITY ; CYTOTOXICITY ; PURIFICATION
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000395473500067
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21994
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Div Biorefinery Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Boyan,Cao, Lili,Zhang, Lijun,et al. Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum[J]. MOLECULES,2017,22(1).
APA Liu, Boyan,Cao, Lili,Zhang, Lijun,Yuan, Xiaofan,&Zhao, Bing.(2017).Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum.MOLECULES,22(1).
MLA Liu, Boyan,et al."Preparation, Phytochemical Investigation, and Safety Evaluation of Chlorogenic Acid Products from Eupatorium adenophorum".MOLECULES 22.1(2017).
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