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Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles
Zheng, Longtang1,3; Wei, Jinhua4; Lv, Xun1; Bi, Yuhai1,9; Wu, Peixing5; Zhang, Zhenxing1,3; Wang, Pengfei1,3; Liu, Ruichen1; Jiang, Jingwen1,3; Cong, Haolong1; Liang, Jingnan6; Cheng, Wenwen7,10; Cao, Hongzhi8; Liu, Wenjun1,9; Gao, George F.1,9; Du, Yuguang4; Jiang, Xingyu7; Li, Xuebing1,2,3,9
2017-05-15
发表期刊BIOSENSORS & BIOELECTRONICS
ISSN0956-5663
卷号91页码:46-52
摘要

Accurate diagnosis of influenza viruses is difficult and generally requires a complex process because of viral diversity and rapid mutability. In this study, we report a simple and rapid strategy for the detection and differentiation of influenza viruses using glycan-functionalized gold nanoparticles (gGNPs). This method is based on the aggregation of gGNP probes on the viral surface, which is mediated by the specific binding of the virus to the glycans. Using a set of gGNPs bearing different glycan structures, fourteen influenza virus strains, including the major subtypes currently circulating in human and avian populations, were readily differentiated from each other and from a human respiratory syncytial virus in a single-step colorimetric procedure. The results presented here demonstrate the potential of this gGNP-based system in the development of convenient and portable sensors for the clinical diagnosis and surveillance of influenza viruses.

关键词Detection Differentiation Glycan Gold Nanoparticles Influenza Virus
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.bios.2016.12.037
收录类别SCI
语种英语
关键词[WOS]Receptor-binding Specificity ; Dynamic Light-scattering ; a H7n9 Virus ; Colorimetric Detection ; Mass-spectrometry ; H1n1 Influenza ; Microarray ; Hemagglutinins ; Neuraminidase ; Assay
WOS研究方向Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
WOS类目Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
项目资助者State Key Research Development Program of China(2016YFC1200302) ; National Natural Science Foundation of China(81661148055 ; Open Project Program of State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences ; Development Fund for Collaborative Innovation Center of Glycoscience of Shandong University ; Open Project Program of National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University ; 31470801 ; 81273381)
WOS记录号WOS:000395599000007
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22110
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China
2.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China
3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China
4.Chinese Acad Sci, PLA Key Lab Biopharmaceut Prod & Formulat Engn, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
5.Chinese Acad Agr Sci, Lanzhou Inst Anim Sci & Vet Pharmaceut, Lanzhou 730050, Peoples R China
6.Chinese Acad Sci, Inst Microbiol, Core Facil, Beijing 100101, Peoples R China
7.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
8.Shandong Univ, Sch Pharmaceut Sci, Natl Glycoengn Res Ctr, Jinan 250012, Peoples R China
9.Chinese Acad Sci CASCIRE, Ctr Influenza Res & Early Warning, Beijing 100101, Peoples R China
10.Shenzhen Univ, Sch Med, Dept Biomed Engn, Shenzhen 518020, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Longtang,Wei, Jinhua,Lv, Xun,et al. Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles[J]. BIOSENSORS & BIOELECTRONICS,2017,91:46-52.
APA Zheng, Longtang.,Wei, Jinhua.,Lv, Xun.,Bi, Yuhai.,Wu, Peixing.,...&Li, Xuebing.(2017).Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles.BIOSENSORS & BIOELECTRONICS,91,46-52.
MLA Zheng, Longtang,et al."Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles".BIOSENSORS & BIOELECTRONICS 91(2017):46-52.
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