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Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice
Parvin, Nargish1,3; Mandal, Tapas K.2,3
2017-04-01
Source PublicationMICROCHIMICA ACTA
ISSN0026-3672
Volume184Issue:4Pages:1117-1125
Abstract

Hydrothermal treatment of a mixture of ethylene diamine, phosphoric acid and citric acid under ambient pressure generates fluorescent carbon dots that are co-doped with phosphorus and nitrogen. These have features such as (a) both green fluorescence (peaking at 430 nm; 30% quantum yield) and red fluorescence (peaking at 500 nm, quantum yield 78%), (b) wavelength-dependent emission peaks, and (c) insensitivity to changes of pH values, dot concentration and ionic strength. The C-dots are useful for both fluorescent (FL) and photoacoustic (PA) imaging of living tissue. PA imaging warrants better spatial resolution and allows deeper tissues to be imaged compared to most optical imaging techniques. It is essential to assign a photoacoustic contrast agent as most of the diseases do not show a natural photoacoustic contrast in their early stage. The dually emitting C-dots are shown to be a useful contrast agent for PA and FL imaging of mice tumors. Intravenous administration of the C-dots resulted in strong signals in both PA and FL imaging.

KeywordCarbon Quantumdots Dual Emission Quantum Yield Wavelength-dependent Emission Toxicity Mouse Tumor Cancer Diagnosis
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1007/s00604-017-2108-4
Indexed BySCI
Language英语
WOS KeywordGraphene Quantum Dots ; Citric-acid ; Phosphorus ; Nanoparticles ; Nitrogen ; Probe ; Photoluminescence ; Oxidation ; Nanodots ; Therapy
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding OrganizationSERB, DST(SR/FT/LS-76/2012) ; DBT Government of India ; TWAS Programme
WOS IDWOS:000397497900017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22134
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttarakhand, India
Recommended Citation
GB/T 7714
Parvin, Nargish,Mandal, Tapas K.. Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice[J]. MICROCHIMICA ACTA,2017,184(4):1117-1125.
APA Parvin, Nargish,&Mandal, Tapas K..(2017).Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice.MICROCHIMICA ACTA,184(4),1117-1125.
MLA Parvin, Nargish,et al."Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice".MICROCHIMICA ACTA 184.4(2017):1117-1125.
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