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Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice
Parvin, Nargish1,3; Mandal, Tapas K.2,3
2017-04-01
发表期刊MICROCHIMICA ACTA
ISSN0026-3672
卷号184期号:4页码:1117-1125
摘要Hydrothermal treatment of a mixture of ethylene diamine, phosphoric acid and citric acid under ambient pressure generates fluorescent carbon dots that are co-doped with phosphorus and nitrogen. These have features such as (a) both green fluorescence (peaking at 430 nm; 30% quantum yield) and red fluorescence (peaking at 500 nm, quantum yield 78%), (b) wavelength-dependent emission peaks, and (c) insensitivity to changes of pH values, dot concentration and ionic strength. The C-dots are useful for both fluorescent (FL) and photoacoustic (PA) imaging of living tissue. PA imaging warrants better spatial resolution and allows deeper tissues to be imaged compared to most optical imaging techniques. It is essential to assign a photoacoustic contrast agent as most of the diseases do not show a natural photoacoustic contrast in their early stage. The dually emitting C-dots are shown to be a useful contrast agent for PA and FL imaging of mice tumors. Intravenous administration of the C-dots resulted in strong signals in both PA and FL imaging.
关键词Carbon Quantumdots Dual Emission Quantum Yield Wavelength-dependent Emission Toxicity Mouse Tumor Cancer Diagnosis
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1007/s00604-017-2108-4
收录类别SCI
语种英语
关键词[WOS]GRAPHENE QUANTUM DOTS ; CITRIC-ACID ; PHOSPHORUS ; NANOPARTICLES ; NITROGEN ; PROBE ; PHOTOLUMINESCENCE ; OXIDATION ; NANODOTS ; THERAPY
WOS研究方向Chemistry
WOS类目Chemistry, Analytical
项目资助者SERB, DST(SR/FT/LS-76/2012) ; DBT Government of India ; TWAS Programme
WOS记录号WOS:000397497900017
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22134
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttarakhand, India
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Parvin, Nargish,Mandal, Tapas K.. Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice[J]. MICROCHIMICA ACTA,2017,184(4):1117-1125.
APA Parvin, Nargish,&Mandal, Tapas K..(2017).Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice.MICROCHIMICA ACTA,184(4),1117-1125.
MLA Parvin, Nargish,et al."Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice".MICROCHIMICA ACTA 184.4(2017):1117-1125.
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