Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice

doi:10.1007/s00604-017-2108-4

CAS OpenIR > 生化工程国家重点实验室

	Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice
	Parvin, Nargish 1,3; Mandal, Tapas K.2,3
	2017-04-01
发表期刊	MICROCHIMICA ACTA
ISSN	0026-3672
卷号	184 期号:4 页码:1117-1125
摘要	Hydrothermal treatment of a mixture of ethylene diamine, phosphoric acid and citric acid under ambient pressure generates fluorescent carbon dots that are co-doped with phosphorus and nitrogen. These have features such as (a) both green fluorescence (peaking at 430 nm; 30% quantum yield) and red fluorescence (peaking at 500 nm, quantum yield 78%), (b) wavelength-dependent emission peaks, and (c) insensitivity to changes of pH values, dot concentration and ionic strength. The C-dots are useful for both fluorescent (FL) and photoacoustic (PA) imaging of living tissue. PA imaging warrants better spatial resolution and allows deeper tissues to be imaged compared to most optical imaging techniques. It is essential to assign a photoacoustic contrast agent as most of the diseases do not show a natural photoacoustic contrast in their early stage. The dually emitting C-dots are shown to be a useful contrast agent for PA and FL imaging of mice tumors. Intravenous administration of the C-dots resulted in strong signals in both PA and FL imaging.
关键词	Carbon Quantumdots Dual Emission Quantum Yield Wavelength-dependent Emission Toxicity Mouse Tumor Cancer Diagnosis
文章类型	Article
WOS标题词	Science & Technology ; Physical Sciences
DOI	10.1007/s00604-017-2108-4
收录类别	SCI
语种	英语
关键词[WOS]	GRAPHENE QUANTUM DOTS ; CITRIC-ACID ; PHOSPHORUS ; NANOPARTICLES ; NITROGEN ; PROBE ; PHOTOLUMINESCENCE ; OXIDATION ; NANODOTS ; THERAPY
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
项目资助者	SERB, DST(SR/FT/LS-76/2012) ; DBT Government of India ; TWAS Programme
WOS记录号	WOS:000397497900017
引用统计
文献类型	期刊论文
条目标识符	http://ir.ipe.ac.cn/handle/122111/22134
专题	生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttarakhand, India
推荐引用方式 GB/T 7714	Parvin, Nargish,Mandal, Tapas K.. Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice[J]. MICROCHIMICA ACTA,2017,184(4):1117-1125.
APA	Parvin, Nargish,&Mandal, Tapas K..(2017).Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice.MICROCHIMICA ACTA,184(4),1117-1125.
MLA	Parvin, Nargish,et al."Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice".MICROCHIMICA ACTA 184.4(2017):1117-1125.