Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice | |
Parvin, Nargish1,3; Mandal, Tapas K.2,3 | |
2017-04-01 | |
Source Publication | MICROCHIMICA ACTA
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ISSN | 0026-3672 |
Volume | 184Issue:4Pages:1117-1125 |
Abstract | Hydrothermal treatment of a mixture of ethylene diamine, phosphoric acid and citric acid under ambient pressure generates fluorescent carbon dots that are co-doped with phosphorus and nitrogen. These have features such as (a) both green fluorescence (peaking at 430 nm; 30% quantum yield) and red fluorescence (peaking at 500 nm, quantum yield 78%), (b) wavelength-dependent emission peaks, and (c) insensitivity to changes of pH values, dot concentration and ionic strength. The C-dots are useful for both fluorescent (FL) and photoacoustic (PA) imaging of living tissue. PA imaging warrants better spatial resolution and allows deeper tissues to be imaged compared to most optical imaging techniques. It is essential to assign a photoacoustic contrast agent as most of the diseases do not show a natural photoacoustic contrast in their early stage. The dually emitting C-dots are shown to be a useful contrast agent for PA and FL imaging of mice tumors. Intravenous administration of the C-dots resulted in strong signals in both PA and FL imaging. |
Keyword | Carbon Quantumdots Dual Emission Quantum Yield Wavelength-dependent Emission Toxicity Mouse Tumor Cancer Diagnosis |
Subtype | Article |
WOS Headings | Science & Technology ; Physical Sciences |
DOI | 10.1007/s00604-017-2108-4 |
Indexed By | SCI |
Language | 英语 |
WOS Keyword | Graphene Quantum Dots ; Citric-acid ; Phosphorus ; Nanoparticles ; Nitrogen ; Probe ; Photoluminescence ; Oxidation ; Nanodots ; Therapy |
WOS Research Area | Chemistry |
WOS Subject | Chemistry, Analytical |
Funding Organization | SERB, DST(SR/FT/LS-76/2012) ; DBT Government of India ; TWAS Programme |
WOS ID | WOS:000397497900017 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ipe.ac.cn/handle/122111/22134 |
Collection | 生化工程国家重点实验室 |
Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttarakhand, India |
Recommended Citation GB/T 7714 | Parvin, Nargish,Mandal, Tapas K.. Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice[J]. MICROCHIMICA ACTA,2017,184(4):1117-1125. |
APA | Parvin, Nargish,&Mandal, Tapas K..(2017).Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice.MICROCHIMICA ACTA,184(4),1117-1125. |
MLA | Parvin, Nargish,et al."Dually emissive P,N-co-doped carbon dots for fluorescent and photoacoustic tissue imaging in living mice".MICROCHIMICA ACTA 184.4(2017):1117-1125. |
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Dually emissive P,N-(2766KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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