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The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli
Ran, Rensen1,2; Zeng, Huan3; Zhao, Dong3; Liu, Ruiyuan1,2; Xu, Xia1
2017-03-01
发表期刊MOLECULES
ISSN1420-3049
卷号22期号:3
摘要Microcin C7 (McC), widely distributed in enterobacteria, is a promising antibiotic against antibiotic resistance. Previous studies have demonstrated that the heptapeptide of McC is only responsible for recognizing the inner membrane transporter YejABEF to deliver McC into microbial cells, but lacks the capacity for inhibiting microbial cell growth. In this study, the effect of the heptapeptide (MR) and two analogues, N-formylated heptapeptide (f-MR) and N-aceylated heptapeptide (a-MR), on microbial cell growth were examined. It is surprising to find that MR not only inhibits the activity of intracellular -galactosidase, respiratory chain dehydrogenases, and 6-phosphogluconate dehydrogenases (6PGDH), but it is also able to inhibit Escherichia coli growth, and eventually leads to cell death at the lethal concentration of 5.34 mM within 10 min. The modification of MR results in a slight increase in the lethal concentration. Cell membrane integrity at the lethal concentration confirms that MR undergoes the inhibition effect, but not by destroying the cell membrane integrity. The novel property of MR provides a new insight into the Trojan horse strategy of McC and opens a new route for antibiotics design.
关键词Microcin C7 Heptapeptide Cell Growth Membrane Integrity
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.3390/molecules22030432
收录类别SCI
语种英语
关键词[WOS]ANTIMICROBIAL PEPTIDE ; OUTER-MEMBRANE ; 6-PHOSPHOGLUCONATE DEHYDROGENASE ; INHIBITOR ; ANTIBIOTICS ; PERMEABILITY ; RESISTANCE ; MECHANISM ; ANOPLIN ; ENTEROBACTERIA
WOS研究方向Chemistry
WOS类目Chemistry, Organic
项目资助者National Natural Science Foundation of China(91534107 ; 201506230)
WOS记录号WOS:000398743500093
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22151
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
3.Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China
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Ran, Rensen,Zeng, Huan,Zhao, Dong,et al. The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli[J]. MOLECULES,2017,22(3).
APA Ran, Rensen,Zeng, Huan,Zhao, Dong,Liu, Ruiyuan,&Xu, Xia.(2017).The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli.MOLECULES,22(3).
MLA Ran, Rensen,et al."The Novel Property of Heptapeptide of Microcin C7 in Affecting the Cell Growth of Escherichia coli".MOLECULES 22.3(2017).
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