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Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway
Xu, Qingsong1; Wang, Wenjing2; Yang, Wen1; Du, Yuguang3; Song, Linsheng1
2017-05-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号98页码:502-505
摘要Chitosan oligosaccharide (COS) has been shown to regulate various cellular and biological functions. Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. The aim of this study was to evaluate the effects of COS on EGF-induced cell growth and the further mechanisms. The results demonstrated that COS could inhibit EGF-induced epithelial GE11 cells proliferation in a dose dependent manner. In addition, EGF stimulated the epithelial cells to undergo morphological alteration, exhibiting mesenchymal cells higher metastatic and invasive potential, however, COS could partly suppress aforementioned morphological change. Signal transduction studies indicated COS repressed epidermal growth factor receptor (EGFR) phosphorylation and mitogen-activated protein kinase (MAPK) activation, but not Grb2, Ras, and Raf. Taken together, chitosan oligosaccharide inhibited EGF-induced cell growth and migration through blockade of the EGFR/MAPK signal transduction pathway. (C) 2017 Elsevier B.V. All rights reserved.
关键词Chitosan Oligosaccharide Epidermal Growth Factor Cell Growth
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.ijbiornac.2017.02.021
收录类别SCI
语种英语
关键词[WOS]TO-MESENCHYMAL TRANSITION ; TUMOR MICROENVIRONMENT ; BREAST-CANCER ; CHITOOLIGOSACCHARIDES ; CHITIN ; ROLES
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
项目资助者National Natural Science Foundation of China(31372347 ; 31670807)
WOS记录号WOS:000396950600056
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22153
专题研究所(批量导入)
作者单位1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
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Xu, Qingsong,Wang, Wenjing,Yang, Wen,et al. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,98:502-505.
APA Xu, Qingsong,Wang, Wenjing,Yang, Wen,Du, Yuguang,&Song, Linsheng.(2017).Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,98,502-505.
MLA Xu, Qingsong,et al."Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 98(2017):502-505.
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