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Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway
Xu, Qingsong1; Wang, Wenjing2; Yang, Wen1; Du, Yuguang3; Song, Linsheng1
2017-05-01
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume98Pages:502-505
Abstract

Chitosan oligosaccharide (COS) has been shown to regulate various cellular and biological functions. Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. The aim of this study was to evaluate the effects of COS on EGF-induced cell growth and the further mechanisms. The results demonstrated that COS could inhibit EGF-induced epithelial GE11 cells proliferation in a dose dependent manner. In addition, EGF stimulated the epithelial cells to undergo morphological alteration, exhibiting mesenchymal cells higher metastatic and invasive potential, however, COS could partly suppress aforementioned morphological change. Signal transduction studies indicated COS repressed epidermal growth factor receptor (EGFR) phosphorylation and mitogen-activated protein kinase (MAPK) activation, but not Grb2, Ras, and Raf. Taken together, chitosan oligosaccharide inhibited EGF-induced cell growth and migration through blockade of the EGFR/MAPK signal transduction pathway. (C) 2017 Elsevier B.V. All rights reserved.

KeywordChitosan Oligosaccharide Epidermal Growth Factor Cell Growth
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.ijbiornac.2017.02.021
Indexed BySCI
Language英语
WOS KeywordTo-mesenchymal Transition ; Tumor Microenvironment ; Breast-cancer ; Chitooligosaccharides ; Chitin ; Roles
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China(31372347 ; 31670807)
WOS IDWOS:000396950600056
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22153
Collection研究所(批量导入)
Affiliation1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qingsong,Wang, Wenjing,Yang, Wen,et al. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,98:502-505.
APA Xu, Qingsong,Wang, Wenjing,Yang, Wen,Du, Yuguang,&Song, Linsheng.(2017).Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,98,502-505.
MLA Xu, Qingsong,et al."Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/imitogen-activated protein kinase pathway".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 98(2017):502-505.
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