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天然Aβ寡聚体抗体的制备研究
王腾; 季梅; 谢喜秀; 汪维云
2016
Source Publication四川大学学报(自然科学版)
Issue3Pages:"652-656"
Abstract

在本研究中,制备了Aβ寡聚体和交联该寡聚体的亲和层析填料,然后应用亲和层析技术从IVIG中纯化获得了结合Aβ寡聚体的多克隆抗体(antibodies against Aβoligomer,Ab-Aβo),并应用ELISA和Western blot对其进行了鉴定,以MTT实验分析了该抗体对Aβ42诱导的细胞毒性作用的影响.结果表明,纯化获得的Ab-Aβo能特异性地结合体外合成或细胞形成的Aβ寡聚体,并且与Aβ寡聚体的结合活性比IVIG高1000倍,同时该寡聚体抗体能够显著抑制Aβ42诱导的细胞毒性.

Keyword阿尔茨海默症 淀粉样蛋白寡聚体 多克隆抗体
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22441
Collection研究所(批量导入)
Recommended Citation
GB/T 7714
王腾,季梅,谢喜秀,等. 天然Aβ寡聚体抗体的制备研究[J]. 四川大学学报(自然科学版),2016(3):"652-656".
APA 王腾,季梅,谢喜秀,&汪维云.(2016).天然Aβ寡聚体抗体的制备研究.四川大学学报(自然科学版)(3),"652-656".
MLA 王腾,et al."天然Aβ寡聚体抗体的制备研究".四川大学学报(自然科学版) .3(2016):"652-656".
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