| Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine | |
| Chen, Zenghui1,2; Zhang, Songping1; Li, Zhengjun1,2; Ma, Guanghui1; Su, Zhiguo1 | |
| 2017 | |
| Source Publication | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
 |
| ISSN | 2169-1401 |
| Volume | 45Issue:5Pages:897-906 |
| Abstract | A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response. |
| Keyword | Adjuvant Foot-and-mouth Disease Vaccine Polyglycerol Polyricinoleate Stability W/o Nano-emulsion |
| Subtype | Article |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine ; Technology |
| DOI | 10.1080/21691401.2016.1188396 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | Mineral-oil Adjuvants ; Polyglycerol Polyricinoleate ; Isopropyl Myristate ; Immune-responses ; Stability ; Caseinate ; Particle ; Sodium ; Mice ; Pigs |
| WOS Research Area | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| WOS Subject | Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, bioMaterials |
| Funding Organization | National Natural Science Foundation of China(21336010) ; National High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Science and Technology Major Project(2013ZX10004606) ; 2014AA021006) |
| WOS ID | WOS:000402039400006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/22623 |
| Collection | 生化工程国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Zenghui,Zhang, Songping,Li, Zhengjun,et al. Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2017,45(5):897-906. |
| APA | Chen, Zenghui,Zhang, Songping,Li, Zhengjun,Ma, Guanghui,&Su, Zhiguo.(2017).Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,45(5),897-906. |
| MLA | Chen, Zenghui,et al."Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 45.5(2017):897-906. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Construction of a st（1798KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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