Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine

doi:10.1080/21691401.2016.1188396

CAS OpenIR > 生化工程国家重点实验室

	Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine
	Chen, Zenghui 1,2; Zhang, Songping 1; Li, Zhengjun 1,2; Ma, Guanghui 1; Su, Zhiguo 1
	2017
发表期刊	ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN	2169-1401
卷号	45 期号:5 页码:897-906
摘要	A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response.
关键词	Adjuvant Foot-and-mouth Disease Vaccine Polyglycerol Polyricinoleate Stability W/o Nano-emulsion
文章类型	Article
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI	10.1080/21691401.2016.1188396
收录类别	SCI
语种	英语
关键词[WOS]	MINERAL-OIL ADJUVANTS ; POLYGLYCEROL POLYRICINOLEATE ; ISOPROPYL MYRISTATE ; IMMUNE-RESPONSES ; STABILITY ; CASEINATE ; PARTICLE ; SODIUM ; MICE ; PIGS
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS类目	Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
项目资助者	National Natural Science Foundation of China(21336010) ; National High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Science and Technology Major Project(2013ZX10004606) ; 2014AA021006)
WOS记录号	WOS:000402039400006
引用统计
文献类型	期刊论文
条目标识符	http://ir.ipe.ac.cn/handle/122111/22623
专题	生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zenghui,Zhang, Songping,Li, Zhengjun,et al. Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2017,45(5):897-906.
APA	Chen, Zenghui,Zhang, Songping,Li, Zhengjun,Ma, Guanghui,&Su, Zhiguo.(2017).Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,45(5),897-906.
MLA	Chen, Zenghui,et al."Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 45.5(2017):897-906.