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Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine
Chen, Zenghui1,2; Zhang, Songping1; Li, Zhengjun1,2; Ma, Guanghui1; Su, Zhiguo1
2017
发表期刊ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN2169-1401
卷号45期号:5页码:897-906
摘要A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response.
关键词Adjuvant Foot-and-mouth Disease Vaccine Polyglycerol Polyricinoleate Stability W/o Nano-emulsion
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1080/21691401.2016.1188396
收录类别SCI
语种英语
关键词[WOS]MINERAL-OIL ADJUVANTS ; POLYGLYCEROL POLYRICINOLEATE ; ISOPROPYL MYRISTATE ; IMMUNE-RESPONSES ; STABILITY ; CASEINATE ; PARTICLE ; SODIUM ; MICE ; PIGS
WOS研究方向Biotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS类目Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
项目资助者National Natural Science Foundation of China(21336010) ; National High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Science and Technology Major Project(2013ZX10004606) ; 2014AA021006)
WOS记录号WOS:000402039400006
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22623
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
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Chen, Zenghui,Zhang, Songping,Li, Zhengjun,et al. Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2017,45(5):897-906.
APA Chen, Zenghui,Zhang, Songping,Li, Zhengjun,Ma, Guanghui,&Su, Zhiguo.(2017).Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,45(5),897-906.
MLA Chen, Zenghui,et al."Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 45.5(2017):897-906.
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