CAS OpenIR  > 生化工程国家重点实验室
Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine
Chen, Zenghui1,2; Zhang, Songping1; Li, Zhengjun1,2; Ma, Guanghui1; Su, Zhiguo1
2017
Source PublicationARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
ISSN2169-1401
Volume45Issue:5Pages:897-906
Abstract

A stable and bio-compatible w/o nano-emulsion was developed as adjuvant for foot and mouth disease (FMD) vaccine with isopropyl myristate as oil phase, polyglycerol polyricinoleate, and Tween 80 as surfactants. Dissolving Tween 80 in aqueous phase decreased the droplet size and improved stability of the emulsion through narrowing size distribution, increasing viscosity, and reducing the interfacial tension between oil and water. The nano-emulsion was then formulated with inactivated FMD virus and ovalbumin to investigate its potential application as an adjuvant. Compared with commercial ISA-206 adjuvant, the novel w/o nano-emulsion was able to induce both humoral- and cell-mediated immune response.

KeywordAdjuvant Foot-and-mouth Disease Vaccine Polyglycerol Polyricinoleate Stability W/o Nano-emulsion
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Technology
DOI10.1080/21691401.2016.1188396
Indexed BySCI
Language英语
WOS KeywordMineral-oil Adjuvants ; Polyglycerol Polyricinoleate ; Isopropyl Myristate ; Immune-responses ; Stability ; Caseinate ; Particle ; Sodium ; Mice ; Pigs
WOS Research AreaBiotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS SubjectBiotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China(21336010) ; National High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Science and Technology Major Project(2013ZX10004606) ; 2014AA021006)
WOS IDWOS:000402039400006
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22623
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zenghui,Zhang, Songping,Li, Zhengjun,et al. Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2017,45(5):897-906.
APA Chen, Zenghui,Zhang, Songping,Li, Zhengjun,Ma, Guanghui,&Su, Zhiguo.(2017).Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,45(5),897-906.
MLA Chen, Zenghui,et al."Construction of a stable w/o nano-emulsion as a potential adjuvant for foot and mouth disease virus vaccine".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 45.5(2017):897-906.
Files in This Item:
File Name/Size DocType Version Access License
Construction of a st(1798KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Zenghui]'s Articles
[Zhang, Songping]'s Articles
[Li, Zhengjun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Zenghui]'s Articles
[Zhang, Songping]'s Articles
[Li, Zhengjun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Zenghui]'s Articles
[Zhang, Songping]'s Articles
[Li, Zhengjun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.