CAS OpenIR  > 生化工程国家重点实验室
Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery
Hou, Yingqin1; Wang, Yaoyi1; Wang, Ruijue3; Bao, Weier2; Xi, Xiaobo2; Sun, Yunlong1; Yang, Shengtao3; Wei, Wei2; Lu, Hua1
2017-05-31
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:21页码:17757-17768
摘要To improve the therapeutic index of cisplatin (CDDP), we present here a new paradigm of drug-induced self-assembly by harnessing phosphato-platinum cornplexation. Specifically, we show that a phosphato-platinum cross-linked micelle (PpY/Pt) can be generated by using a block copolymer methoxy-poly(ethylene glycol)block-poly(L-phosphotyrosine) (mPEG-b-PpY). Coating of PpY/Pt with aR9-iRGD peptide by simple mixing affords a targeting micelle with near neutral-charged surface (iPpY/Pt). The micelles feature in well-controlled sizes below 50 nm and high, stability under physiological conditions, and can withstand various environmental stresses. Importantly, the micelles demonstrate on-demand drug release profiles in response to pathological cues such as high ATP concentration and acidic pH. In vitro, the micelles are efficiently internalized and almost equally potent compared to CDDP. Moreover, iPpY/Pt induce greater cytotoxicity than PpY/Pt in a 3D tumor spheroid model likely due to its deeper tumor penetration. In vivo, the micelles exhibit prolonged circulation half-lives, enhanced tumor accumulation, excellent tumor growth inhibition in a xenograft HeLa model and an orthotropic mammary 4T1 model, and improved safety profiles evidenced by the reduced nephrotoxicity. Together) this work demonstrates for the first time that phosphato-platinurn complexation can be exploited for effective delivery of CDDP, and suggests a paradigm shift of constructing nanosystems for other anticancer metallodrugs.
关键词Poly(Phosphotyrosine) Cisplatin Atp-responsive Drug Delivery Irgd
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.7b03686
收录类别SCI
语种英语
关键词[WOS]ANTICANCER DRUG-DELIVERY ; ENHANCE THERAPEUTIC-EFFICACY ; RING-OPENING POLYMERIZATION ; OVARIAN-CANCER CELLS ; PT(IV) PRO-DRUG ; TARGETED DELIVERY ; CO-DELIVERY ; ANTITUMOR EFFICACY ; BLADDER-CANCER ; BREAST-CANCER
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Key Research and Development Program of China(2016YFA0201400) ; National Natural Science Foundation of China(21434008 ; Open Funding Project of the State Key Laboratory of Biochemical Engineering(2015KF-01) ; Beijing Talents Fund(2015000021223ZK20) ; 21622608)
WOS记录号WOS:000402691600011
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22637
专题生化工程国家重点实验室
作者单位1.Peking Univ, Beijing Natl Lab Mol Sci, Minist Educ,Coll Chem & Mol Engn, Ctr Soft Matter Sci & Engn,Key Lab Polymer Chem &, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 10090, Peoples R China
3.Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China
推荐引用方式
GB/T 7714
Hou, Yingqin,Wang, Yaoyi,Wang, Ruijue,et al. Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(21):17757-17768.
APA Hou, Yingqin.,Wang, Yaoyi.,Wang, Ruijue.,Bao, Weier.,Xi, Xiaobo.,...&Lu, Hua.(2017).Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery.ACS APPLIED MATERIALS & INTERFACES,9(21),17757-17768.
MLA Hou, Yingqin,et al."Harnessing Phosphato-Platinum Bonding Induced Supramolecular Assembly for Systemic Cisplatin Delivery".ACS APPLIED MATERIALS & INTERFACES 9.21(2017):17757-17768.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hou, Yingqin]的文章
[Wang, Yaoyi]的文章
[Wang, Ruijue]的文章
百度学术
百度学术中相似的文章
[Hou, Yingqin]的文章
[Wang, Yaoyi]的文章
[Wang, Ruijue]的文章
必应学术
必应学术中相似的文章
[Hou, Yingqin]的文章
[Wang, Yaoyi]的文章
[Wang, Ruijue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。