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Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure
Xu, Qingsong1; Wang, Wenjing2; Qu, Chen1; Gu, Jianguo3; Yin, Heng4; Jia, Zhihao1; Song, Linsheng1; Du, Yuguang5
2017-08-15
发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
卷号170页码:241-246
摘要Chitosan oligosaccharides (COS) have been shown to regulate various cellular and biological functions. The aim of this study was to investigate the antimetastatic potency of COS and the underlying mechanism. Here, we established a stably N-acetylglucosaminyltransferase V (GnT-V)-overexpressed MCF10A cell line. As expected, GnT-V overexpression greatly promoted cell migration in the transfectants by using wound healing assay. However, the induction in the cell migration was significantly suppressed by an addition of COS. Curiously, COS inhibited the protein expression of GnT-V in a dose dependent manner. Consistent with that, the reactivities with datura stramonium (DSA) and leuko-agglutinating phytohemagglutinin (L4-PHA) lectins, which specifically recognize branched N-acetylglucosamine (Gic-NAc) structure, were also suppressed by COS. Taken together, these results demonstrated COS inhibited breast epithelial cell migration through down-regulation of GnT-V and its products, branched N-glycans, indicating that COS may serve as a potential novel therapeutic candidate for the treatment of metastatic breast cancer. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Chitosan Oligosaccharides N-acetylglucosaminyltransferase v Branched N-glycan Cell Migration
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2017.04.075
收录类别SCI
语种英语
关键词[WOS]MOLECULAR-WEIGHT ; CANCER-CELLS ; TUMOR-GROWTH ; KAPPA-B ; GNT-V ; CHITOOLIGOSACCHARIDES ; METASTASIS ; ADHESION ; SUPPRESSION ; SECRETASE
WOS研究方向Chemistry ; Polymer Science
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
项目资助者National Natural Science Foundation of China(31372347 ; 31670807)
WOS记录号WOS:000402942900028
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22660
专题研究所(批量导入)
作者单位1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China
3.Tohoku Med & Pharmaceut Univ, Sendai, Miyagi 9818558, Japan
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
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Xu, Qingsong,Wang, Wenjing,Qu, Chen,et al. Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure[J]. CARBOHYDRATE POLYMERS,2017,170:241-246.
APA Xu, Qingsong.,Wang, Wenjing.,Qu, Chen.,Gu, Jianguo.,Yin, Heng.,...&Du, Yuguang.(2017).Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure.CARBOHYDRATE POLYMERS,170,241-246.
MLA Xu, Qingsong,et al."Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure".CARBOHYDRATE POLYMERS 170(2017):241-246.
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