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题名:
Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure
作者: Xu, Qingsong1; Wang, Wenjing2; Qu, Chen1; Gu, Jianguo3; Yin, Heng4; Jia, Zhihao1; Song, Linsheng1; Du, Yuguang5
刊名: CARBOHYDRATE POLYMERS
出版日期: 2017-08-15
卷号: 170, 页码:241-246
关键词: Chitosan oligosaccharides ; N-Acetylglucosaminyltransferase V ; Branched N-glycan ; Cell migration
收录类别: SCI
WOS记录号: WOS:000402942900028
DOI: 10.1016/j.carbpol.2017.04.075
文章类型: Article
英文摘要: Chitosan oligosaccharides (COS) have been shown to regulate various cellular and biological functions. The aim of this study was to investigate the antimetastatic potency of COS and the underlying mechanism. Here, we established a stably N-acetylglucosaminyltransferase V (GnT-V)-overexpressed MCF10A cell line. As expected, GnT-V overexpression greatly promoted cell migration in the transfectants by using wound healing assay. However, the induction in the cell migration was significantly suppressed by an addition of COS. Curiously, COS inhibited the protein expression of GnT-V in a dose dependent manner. Consistent with that, the reactivities with datura stramonium (DSA) and leuko-agglutinating phytohemagglutinin (L4-PHA) lectins, which specifically recognize branched N-acetylglucosamine (Gic-NAc) structure, were also suppressed by COS. Taken together, these results demonstrated COS inhibited breast epithelial cell migration through down-regulation of GnT-V and its products, branched N-glycans, indicating that COS may serve as a potential novel therapeutic candidate for the treatment of metastatic breast cancer. (C) 2017 Elsevier Ltd. All rights reserved.
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Chemistry, Applied ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Chemistry ; Polymer Science
关键词[WOS]: MOLECULAR-WEIGHT ; CANCER-CELLS ; TUMOR-GROWTH ; KAPPA-B ; GNT-V ; CHITOOLIGOSACCHARIDES ; METASTASIS ; ADHESION ; SUPPRESSION ; SECRETASE
项目资助者: National Natural Science Foundation of China(31372347 ; 31670807)
语种: 英语
ISSN号: 0144-8617
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内容类型: 期刊论文
URI标识: http://ir.ipe.ac.cn/handle/122111/22660
Appears in Collections:研究所(批量导入)_期刊论文

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作者单位: 1.Dalian Ocean Univ, Coll Fisheries & Life Sci, 52 Heishijiao St, Dalian 116023, Peoples R China
2.Dalian Elite Analyt Instruments Co Ltd, Dalian 116023, Peoples R China
3.Tohoku Med & Pharmaceut Univ, Sendai, Miyagi 9818558, Japan
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China

Recommended Citation:
Xu, Qingsong,Wang, Wenjing,Qu, Chen,et al. Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure[J]. CARBOHYDRATE POLYMERS,2017,170:241-246.
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