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One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery
Zhou, Mengyun1; Du, Xin1; Li, Weike1; Li, Xiaoyu2; Huang, Hongwei3; Liao, Qingliang4; Shi, Bingyang5; Zhang, Xueji1; Zhang, Meiqin1
2017-06-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume5Issue:23Pages:4455-4469
Abstract

Biodegradability is very critical for biomaterials to be nanocarriers. Ideal nanocarriers should be stable enough to execute their functions, but then can be efficiently got rid of, by either biodegradation or excretion. In this work, we report the design and one-pot fabrication of a series of uniform organic-inorganic hybrid nanocapsules with a disulfide-bridged silsesquioxane framework and a particle size smaller than 100 nm for redox-triggered biodegradation. The optimal synthesis conditions were explored for balancing the nanostructure, sulfur (S) content and aggregation degree. Fluorescent molecules were also integrated into the disulfide-bridged silsesquioxane framework by a co-condensation strategy for fluorescence tracking. Dithiothreitol (DTT) as a strong model reducing agent triggered the breakdown of hybrid nanocapsules without and with PEG modification from intact nanospheres to small fragments, while intracellular glutathione (GSH) had a slightly lower capacity of biodegrading these nanocapsules. The constructed delivery system obviously inhibited the growth of A549 cancer cells due to efficient cellular uptake by an endocytosis pathway and the subsequent pH and GSH-triggered drug release. The possibility of regulating the framework and surface functionalization of hybrid nanocapsules opens new opportunities for the development of silica-based degradable hybrid nanocarriers for promising drug delivery.

SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c6tb03368g
Indexed BySCI
Language英语
WOS KeywordMesoporous Silica Nanoparticles ; Organosilica Nanoparticles ; Biomedical Applications ; Poly(Ethylene Glycol) ; Degradation Behavior ; Controlled-release ; Protein Delivery ; Gene Delivery ; Chemistry ; Therapy
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China(21501009) ; High-Level Talent Introduction Plan of the University of Science & Technology Beijing (USTB)(06500017) ; Fundamental Research Funds for the Central Universities(FRF-TP-15-019A1) ; State Key Laboratory of Biochemical Engineering(2014KF-05) ; Construction of Distinctive Science of School of Chemistry and Biological Engineering from the Fundamental Research Funds of USTB(2302015frf-br-15-008b)
WOS IDWOS:000403367000017
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22726
Collection湿法冶金清洁生产技术国家工程实验室
Affiliation1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing Key Lab Bioengn & Sensing Technol, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydromet Cleaner Prod Technol, State Key Lab Biochem Engn,Key Lab Green Proc & E, Beijing 100190, Peoples R China
3.China Univ Geosci, Sch Mat Sci & Technol, Beijing 100083, Peoples R China
4.Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Sch Mat Sci & Engn, Beijing Municipal Key Lab New Energy Mat & Techno, Beijing 100083, Peoples R China
5.Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW 2109, Australia
Recommended Citation
GB/T 7714
Zhou, Mengyun,Du, Xin,Li, Weike,et al. One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(23):4455-4469.
APA Zhou, Mengyun.,Du, Xin.,Li, Weike.,Li, Xiaoyu.,Huang, Hongwei.,...&Zhang, Meiqin.(2017).One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery.JOURNAL OF MATERIALS CHEMISTRY B,5(23),4455-4469.
MLA Zhou, Mengyun,et al."One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery".JOURNAL OF MATERIALS CHEMISTRY B 5.23(2017):4455-4469.
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