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A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease
Wang, Shao-wei1; Liu, Dong-qun1; Zhang, Ling-xiao1; Ji, Mei1; Zhang, Yang-xin1,2; Dong, Quan-xiu1; Liu, Shu-ying1,3; Xie, Xi-xiu1; Liu, Rui-tian1
2017-06-07
发表期刊ALZHEIMERS RESEARCH & THERAPY
ISSN1758-9193
卷号9
摘要

Background: beta-Amyloid peptide (A beta) oligomers are initial factors used to induce Alzheimer's disease (AD) development, and A beta monomers have normal physiological function. The antibodies or vaccines against A beta monomers have serious problems, such as side effects and low curative effects. Therefore, it is essential to specifically target A beta oligomers rather than monomers for the treatment of AD.

关键词Alzheimer's Disease Beta-amyloid Oligomer Mimotope Saccharomyces Cerevisiae Vaccine
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1186/s13195-017-0267-5
收录类别SCI
语种英语
关键词[WOS]Amyloid-beta ; Vanutide Cridificar ; Qs-21 Adjuvant ; Phase-3 Trials ; 2-phase 2 ; Immunotherapy ; Autoantibodies ; Immunization ; Mechanism ; Peptide
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology ; Neurosciences
项目资助者National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2012ZX09103301-001 ; 31471720 ; 2014ZX09102045-006) ; 31101335)
WOS记录号WOS:000403027200001
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22798
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China
3.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China
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Wang, Shao-wei,Liu, Dong-qun,Zhang, Ling-xiao,et al. A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9.
APA Wang, Shao-wei.,Liu, Dong-qun.,Zhang, Ling-xiao.,Ji, Mei.,Zhang, Yang-xin.,...&Liu, Rui-tian.(2017).A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease.ALZHEIMERS RESEARCH & THERAPY,9.
MLA Wang, Shao-wei,et al."A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease".ALZHEIMERS RESEARCH & THERAPY 9(2017).
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