CAS OpenIR  > 生化工程国家重点实验室
A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease
Wang, Shao-wei1; Liu, Dong-qun1; Zhang, Ling-xiao1; Ji, Mei1; Zhang, Yang-xin1,2; Dong, Quan-xiu1; Liu, Shu-ying1,3; Xie, Xi-xiu1; Liu, Rui-tian1
2017-06-07
Source PublicationALZHEIMERS RESEARCH & THERAPY
ISSN1758-9193
Volume9
Abstract

Background: beta-Amyloid peptide (A beta) oligomers are initial factors used to induce Alzheimer's disease (AD) development, and A beta monomers have normal physiological function. The antibodies or vaccines against A beta monomers have serious problems, such as side effects and low curative effects. Therefore, it is essential to specifically target A beta oligomers rather than monomers for the treatment of AD.

KeywordAlzheimer's Disease Beta-amyloid Oligomer Mimotope Saccharomyces Cerevisiae Vaccine
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1186/s13195-017-0267-5
Indexed BySCI
Language英语
WOS KeywordAmyloid-beta ; Vanutide Cridificar ; Qs-21 Adjuvant ; Phase-3 Trials ; 2-phase 2 ; Immunotherapy ; Autoantibodies ; Immunization ; Mechanism ; Peptide
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
Funding OrganizationNational Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2012ZX09103301-001 ; 31471720 ; 2014ZX09102045-006) ; 31101335)
WOS IDWOS:000403027200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22798
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China
3.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China
Recommended Citation
GB/T 7714
Wang, Shao-wei,Liu, Dong-qun,Zhang, Ling-xiao,et al. A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease[J]. ALZHEIMERS RESEARCH & THERAPY,2017,9.
APA Wang, Shao-wei.,Liu, Dong-qun.,Zhang, Ling-xiao.,Ji, Mei.,Zhang, Yang-xin.,...&Liu, Rui-tian.(2017).A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease.ALZHEIMERS RESEARCH & THERAPY,9.
MLA Wang, Shao-wei,et al."A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease".ALZHEIMERS RESEARCH & THERAPY 9(2017).
Files in This Item:
File Name/Size DocType Version Access License
A vaccine with A bet(9258KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Shao-wei]'s Articles
[Liu, Dong-qun]'s Articles
[Zhang, Ling-xiao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Shao-wei]'s Articles
[Liu, Dong-qun]'s Articles
[Zhang, Ling-xiao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Shao-wei]'s Articles
[Liu, Dong-qun]'s Articles
[Zhang, Ling-xiao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.