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Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution
Wang, Anhe1; Cui, Lingyun1; Debnath, Sisir2; Dong, Qianqian1; Yan, Xuehai1; Zhang, Xi3; Ulijn, Rein V.2,4,5,6; Bai, Shuo1

Solvent molecules significantly affect the supramolecular self-assembly, for example, in forming solvent-bridged hydrogen bonding networks. Even small changes in solvent composition can have dramatic impact on supramolecular assembly. Herein, we demonstrate the use of trace solvents (as low as 0.04%) to tune the morphology and consequent functions of supramolecular nanostructures based on an aromatic peptide bola-amphiphile. Specifically, perylene bisimide-(di)glycine-tyrosine (PBI-[GY](2)) bola-amphiphile was shown to give rise to red-emitting nanofibers when assembled in water, while exposure to trace organic solvents such as tetrahydrofuran (THF) and others via solvent-evaporation followed by aqueous assembly gave rise to white-light-emitting nanospheres. Differential hydrogen bonding between water (donor and acceptor) and THF (acceptor only) impacts supramolecular organization, which was verified using a density functional theory (DFT) simulation. The tunable consequent surface hydrophobicity was utilized in staining the cytoplasm and membrane of cells, respectively. The trace-solvent effect achieved through evaporationdissolution provides a methodology to mediate the morphologies and consequent functions for supramolecular biomaterials controlled by the self-assembly pathway.

KeywordTrace Solvent Peptide Self-assembly Nanostructure White Light Emission Cell Staining
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS KeywordPerylene Bisimide ; Live Cells ; Water ; Biomaterials ; Fabrication ; Matter
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21644007) ; Talent Fund of the Recruitment Program of Global Youth Experts
WOS IDWOS:000404807200040
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
3.Tsinghua Univ, Dept Chem, MOE Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China
4.CUNY, ASRC, New York, NY 10031 USA
5.CUNY Hunter Coll, Dept Chem & Biochem, 695 Pk Ave, New York, NY 10065 USA
6.CUNY, Grad Ctr, New York, NY 10016 USA
Recommended Citation
GB/T 7714
Wang, Anhe,Cui, Lingyun,Debnath, Sisir,et al. Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21390-21396.
APA Wang, Anhe.,Cui, Lingyun.,Debnath, Sisir.,Dong, Qianqian.,Yan, Xuehai.,...&Bai, Shuo.(2017).Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution.ACS APPLIED MATERIALS & INTERFACES,9(25),21390-21396.
MLA Wang, Anhe,et al."Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21390-21396.
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