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Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy
Li, Yuan1; Li, Wei2,4; Bao, Weier2; Liu, Bin1; Li, Dan1; Jiang, Yumeng1; Wei, Wei3; Ren, Fazheng1
2017-07-21
Source PublicationNANOSCALE
ISSN2040-3364
Volume9Issue:27Pages:9317-9324
Abstract

Combination therapy with enhanced therapeutic and antimetastatic efficacy has become promising for cancer treatment. There is an urgent need to design a co-delivery system to sequentially release the drug pair at desired locations that can increase the intra-tumoral drug concentration and reduce the side effects. Inspired by virus architecture and function, herein, we developed a peptosome (PS)-based codelivery system, PePm/PS/Curcumin (Cur), for the sequential release of the therapeutic peptide Pe and chemodrug Cur. PS was formed by the self-assembly of amphiphilic a-lactalbumin peptides obtained from enzymatic partial hydrolysis. Then, PS was self-cross-linked with disulfide bonds utilizing their endogenous thiol groups. The system is responsive to multiple tumor microenvironments and releases the drugs at specific tumor locations. First, after PS accumulation in tumor tissue via the EPR effect, the linkage peptide Pm in PS can be cleaved by matrix metalloproteinases (MMP) enzymatic hydrolysis. Pe can stay on the cell surface and antagonize the ErbB-2 receptor expression on the tumor cells. Moreover, the positively charged nature of remaining Mal-PS/Cur facilitates tumor cell internalization and induces a subsequent proton-sponge effect for lysosomal escape. Finally, Cur is released in the cytoplasm via a reduction-induced PS disassembly due to the high level of intracellular GSH. Both the in vitro and in vivo results exhibited an enhanced antitumor and antimetastatic efficacy of this system.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c7nr00598a
Indexed BySCI
Language英语
WOS KeywordGlycol Chitosan Nanoparticles ; Peptide/p53 Dna ; Cancer-therapy ; Breast-cancer ; Quantum Dots ; Co-delivery ; Cells ; Therapeutics ; Apoptosis ; Micelle
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational Natural Science Foundation of China(31471577) ; Beijing Nova Program(Z141102001814066)
WOS IDWOS:000405387100008
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22808
Collection生化工程国家重点实验室
Affiliation1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Key Lab Funct Dairy, Beijing 100083, Peoples R China
2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
Recommended Citation
GB/T 7714
Li, Yuan,Li, Wei,Bao, Weier,et al. Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy[J]. NANOSCALE,2017,9(27):9317-9324.
APA Li, Yuan.,Li, Wei.,Bao, Weier.,Liu, Bin.,Li, Dan.,...&Ren, Fazheng.(2017).Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy.NANOSCALE,9(27),9317-9324.
MLA Li, Yuan,et al."Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy".NANOSCALE 9.27(2017):9317-9324.
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