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Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy
Li, Yuan1; Li, Wei2,4; Bao, Weier2; Liu, Bin1; Li, Dan1; Jiang, Yumeng1; Wei, Wei3; Ren, Fazheng1
2017-07-21
发表期刊NANOSCALE
ISSN2040-3364
卷号9期号:27页码:9317-9324
摘要

Combination therapy with enhanced therapeutic and antimetastatic efficacy has become promising for cancer treatment. There is an urgent need to design a co-delivery system to sequentially release the drug pair at desired locations that can increase the intra-tumoral drug concentration and reduce the side effects. Inspired by virus architecture and function, herein, we developed a peptosome (PS)-based codelivery system, PePm/PS/Curcumin (Cur), for the sequential release of the therapeutic peptide Pe and chemodrug Cur. PS was formed by the self-assembly of amphiphilic a-lactalbumin peptides obtained from enzymatic partial hydrolysis. Then, PS was self-cross-linked with disulfide bonds utilizing their endogenous thiol groups. The system is responsive to multiple tumor microenvironments and releases the drugs at specific tumor locations. First, after PS accumulation in tumor tissue via the EPR effect, the linkage peptide Pm in PS can be cleaved by matrix metalloproteinases (MMP) enzymatic hydrolysis. Pe can stay on the cell surface and antagonize the ErbB-2 receptor expression on the tumor cells. Moreover, the positively charged nature of remaining Mal-PS/Cur facilitates tumor cell internalization and induces a subsequent proton-sponge effect for lysosomal escape. Finally, Cur is released in the cytoplasm via a reduction-induced PS disassembly due to the high level of intracellular GSH. Both the in vitro and in vivo results exhibited an enhanced antitumor and antimetastatic efficacy of this system.

文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1039/c7nr00598a
收录类别SCI
语种英语
关键词[WOS]Glycol Chitosan Nanoparticles ; Peptide/p53 Dna ; Cancer-therapy ; Breast-cancer ; Quantum Dots ; Co-delivery ; Cells ; Therapeutics ; Apoptosis ; Micelle
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
项目资助者National Natural Science Foundation of China(31471577) ; Beijing Nova Program(Z141102001814066)
WOS记录号WOS:000405387100008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22808
专题生化工程国家重点实验室
作者单位1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Key Lab Funct Dairy, Beijing 100083, Peoples R China
2.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
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GB/T 7714
Li, Yuan,Li, Wei,Bao, Weier,et al. Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy[J]. NANOSCALE,2017,9(27):9317-9324.
APA Li, Yuan.,Li, Wei.,Bao, Weier.,Liu, Bin.,Li, Dan.,...&Ren, Fazheng.(2017).Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy.NANOSCALE,9(27),9317-9324.
MLA Li, Yuan,et al."Bioinspired peptosomes with programmed stimuli-responses for sequential drug release and high-performance anticancer therapy".NANOSCALE 9.27(2017):9317-9324.
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