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Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides
Zhang, Guiqiang1,2,3; Jia, Peiyuan1,2; Cheng, Gong1,2; Jiao, Siming1,2; Ren, Lishi1,2; Ji, Shaoyang1,2; Hu, Tao1,2; Liu, Hongtao1,2; Du, Yuguang1,2
2017-06-15
发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
卷号166页码:64-72
摘要This study aimed to investigate the effect of chitosan oligosaccharide (COS) conjugation on the immunogenicity of porcine circovirus type-2 (PCV2) vaccine. Two conjugates (PCV2-COS-1 and PCV2-COS-2) were designed by covalent conjugation of an inactivated PCV2 vaccine with COS, and administered to C57BL/6 mice three times at two-week intervals. The results indicate that, as compared to PCV2 alone group, the PCV2-COS conjugates remarkably enhanced both humoral and cellular immunity against PCV2 by promoting T lymphocyte proliferation and initiating a mixed Th1/Th2 response, including the elevated production of PCV-2 specific antibodies and up-regulated secretion of inflammatory cytoldnes. Noticeably, the immunization with PCV2-COS-1 conjugate displayed similar or even better immune-stimulating effects than that by PCV2/ISA206 (a commercialized adjuvant) and showed no infection or pathological signs at injection sites of the mice. Presumably, the covalent linkage of PCV2 vaccine to COS might be a viable strategy to increase the efficacy against PCV2-associated diseases. (C) 2017 Elsevier Ltd. All rights reserved.
关键词Porcine Circovirus Type 2 (Pcv2) Vaccine Adjuvant Chitosan Oligosaccharide Conjugation
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2017.02.058
收录类别SCI
语种英语
关键词[WOS]T-CELL IMMUNITY ; DENDRITIC CELLS ; ANTIGEN ; RECEPTOR ; MICE ; IMMUNOGENICITY ; EFFICACY ; VIREMIA ; LIGAND ; PIGS
WOS研究方向Chemistry ; Polymer Science
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
项目资助者National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; National Natural Science Fund of China(31500747 ; Postdoctoral Science Fund of China(2014M561069) ; 31570801)
WOS记录号WOS:000400213300007
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22817
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, PLA, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, PLA, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Guiqiang,Jia, Peiyuan,Cheng, Gong,et al. Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides[J]. CARBOHYDRATE POLYMERS,2017,166:64-72.
APA Zhang, Guiqiang.,Jia, Peiyuan.,Cheng, Gong.,Jiao, Siming.,Ren, Lishi.,...&Du, Yuguang.(2017).Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides.CARBOHYDRATE POLYMERS,166,64-72.
MLA Zhang, Guiqiang,et al."Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides".CARBOHYDRATE POLYMERS 166(2017):64-72.
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