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Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice
Zhang, Lijun1,2; Zhao, Qingsheng1; Wang, Liwei1; Zhao, Mingxia1; Zhao, Bing1
2017-06-01
发表期刊INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
卷号99页码:63-70
摘要To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3 kDa and the polysaccharide purity was 91.63%. In order to assess the antioxidant activities of MP-1, four kinds of methods were used, including scavenging hydroxyl radical, DPPH, superoxide anion radical, and FRAP, and the results indicated high antioxidant activities. Furthermore, hepatoprotective activity of MP-1 was studied both in vitro and vivo. In vitro, the alcohol induced Hep-G2 cells model was established to evaluate the protective effect of MP-1, which demonstrated MP-1 can alleviate alcohol damage in Hep-G2 cells. In vivo, the Institute of Cancer Researcch (ICR) mice were used to evaluate hepatoprotecive effects of MP-1 on alcoholic liver disease (ALD). Supplement with MP-1 supressed the triglyceride level both in serum and in hepatic tissue. In addition, MP-1 ameliorated serous transaminases increase induced by alcohol, including aspartate transaminase, alanine aminotransferase, and gamma-glutamyl transpeptidase. Moreover, MP-1 also dramatically increased the superoxide dismutase, glutathione peroxidase, and glutathione s-transferase levels in alcoholic mice. Meantime, histopathologic results MP-1 lighten inflammation induced by alcohol. These results indicate that MP-1 possesses hepatoprotective activity against hepatic injury induced by alcohol. (C) 2017 Elsevier B.V. All rights reserved.
关键词Lepidium Meyenii Polysaccharide Alcoholic Liver Oxidative Injury Liver Protective Effect
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.ijbiomac.2017.01.125
收录类别SCI
语种英语
关键词[WOS]ANTIOXIDANT ACTIVITY ; DISEASE ; EXTRACT ; RATS ; SUPPLEMENTATION ; CAPACITY ; BURDEN
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
项目资助者National High Technology Research and Development Program of China (863 Program)(2012AA021702-4)
WOS记录号WOS:000400034100008
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22831
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Div Biorefineiy Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Zhang, Lijun,Zhao, Qingsheng,Wang, Liwei,et al. Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,99:63-70.
APA Zhang, Lijun,Zhao, Qingsheng,Wang, Liwei,Zhao, Mingxia,&Zhao, Bing.(2017).Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,99,63-70.
MLA Zhang, Lijun,et al."Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 99(2017):63-70.
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