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Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR
Li, Yaqiong1; Li, Xiunan2; Chen, Chao2; Zhao, Dawei2; Su, Zhiguo2,3; Ma, Guanghui2; Yu, Rong1
2017-01-21
Source PublicationJOURNAL OF POLYMER RESEARCH
ISSN1022-9760
Volume24Issue:2
Abstract

Sol-gel transition properties play a key role in various applications of thermosensitive hydrogels, but conventional methods for studying the sol-gel transition have some limitations. For extensive characterization of the water-polymer interaction and microstructure change during sol-gel transition, we propose a rapid and nondestructive method based on monitoring water mobility through low field NMR (LF-NMR), and this was applied to chitosan/beta-glycerophosphate (CS/GP) hydrogels. The spin-spin relaxation time (T-2) that depicted water mobility was measured by LF-NMR within 90 s. The T-2 component corresponding to water protons trapped in polymer networks (T-21) was very sensitive to sol-gel transition. A remarkable decrease of T-21 value indicated obvious variations of water mobility when CS/GP was heated, and a turning point was observed on the T-21-time curve. The gel point associated with this turning point could be easily determined by fitting the T-21-time curves to a bilinear regression model, and the results showed good accuracy and repeatability owing to the nondestructive nature of LF-NMR. Variations in water components and microstructure of CS/GP caused by water migration after solidification were also analyzed by monitoring dynamic changes of T-2. This rapid, nondestructive method provides a powerful tool for studying the sol-gel transition of hydrogels.

KeywordLf-nmr T-2 Sol-gel Transition Water Mobility Microstructure
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1007/s10965-017-1185-8
Indexed BySCI
Language英语
WOS KeywordIn-situ ; Triblock Copolymer ; Controlled-release ; Kappa-carrageenan ; Biscuit Dough ; Lung Injury ; Gelation ; Chitosan ; Temperature ; Relaxation
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationNational High Technology Research and Development Program of China(2014AA021005 ; National Natural Science Foundation of China(21376248 ; National Key Scientific Instrument and Equipment Development Project(2013YQ14040508) ; Doctoral Fund of the Ministry of Education(20120181110036) ; National Basic Research Program(2013CB733604) ; Opening Foundation of National Key Laboratory of Biochemical Engineering(2014KF-4) ; 2014AA021006) ; 21506228)
WOS IDWOS:000400379400001
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22843
Collection生化工程国家重点实验室
Affiliation1.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Li, Yaqiong,Li, Xiunan,Chen, Chao,et al. Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR[J]. JOURNAL OF POLYMER RESEARCH,2017,24(2).
APA Li, Yaqiong.,Li, Xiunan.,Chen, Chao.,Zhao, Dawei.,Su, Zhiguo.,...&Yu, Rong.(2017).Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR.JOURNAL OF POLYMER RESEARCH,24(2).
MLA Li, Yaqiong,et al."Sol-gel transition characterization of thermosensitive hydrogels based on water mobility variation provided by low field NMR".JOURNAL OF POLYMER RESEARCH 24.2(2017).
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