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Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties
Wang, Quan1; Zhang, Ruirui2,3; Lu, Mingzi1; You, Guoxing1; Wang, Ying1; Chen, Gan1; Zhao, Caiyan2; Wang, Zhen1; Song, Xiang1; Wu, Yan2; Zhao, Lian1; Zhou, Hong1
2017-04-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume18Issue:4Pages:1333-1341
Abstract

Oxidative side reaction is one of the major factors hindering the development of hemoglobin-based oxygen carriers (HBOCs). To avoid the oxidative toxicity, we designed and synthesized polydopamine-coated hemoglobin (Hb-PDA) nanoparticles via simple one-step assemblage without any toxic reagent. Hb-PDA nanoparticles showed oxidative protection of Hb by inhibiting the generation of methemoglobin (MetHb) and ferryl (Fe IV) Hb, as well as excellent antioxidant properties by scavenging free radicals and reactive oxygen species (ROS). Interestingly, the scavenging rate of Hb-PDA nanoparticles for ABTS(+) radical is at most 89%, while for DPPH radical it reaches 49%. In addition, Hb-PDA efficiently reduced the intracellular H2O2-induced ROS generation. Moreover, Hb-PDA nanoparticles exhibited high oxygen affinity, low effect on blood constituents, and low cytotoxicity. The results indicate that polydopamine-coated hemoglobin might be a promising approach for constructing novel oxygen carriers with the capacity to reduce oxidative side reaction.

SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.biomac.7b00077
Indexed BySCI
Language英语
WOS KeywordRed-blood-cells ; Heme Degradation ; Cross-linking ; In-vitro ; Nanoparticles ; Substitutes ; Glutaraldehyde ; Methemoglobin ; Assemblies ; Protection
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China(31271001) ; Beijing Natural Science Foundation(2174085)
WOS IDWOS:000399061100028
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22846
Collection多相复杂系统国家重点实验室
Affiliation1.Beijing Inst Transfus Med, Beijing Key Lab Blood Safety & Supply Technol, Beijing 100039, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Quan,Zhang, Ruirui,Lu, Mingzi,et al. Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties[J]. BIOMACROMOLECULES,2017,18(4):1333-1341.
APA Wang, Quan.,Zhang, Ruirui.,Lu, Mingzi.,You, Guoxing.,Wang, Ying.,...&Zhou, Hong.(2017).Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties.BIOMACROMOLECULES,18(4),1333-1341.
MLA Wang, Quan,et al."Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties".BIOMACROMOLECULES 18.4(2017):1333-1341.
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