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Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties
Wang, Quan1; Zhang, Ruirui2,3; Lu, Mingzi1; You, Guoxing1; Wang, Ying1; Chen, Gan1; Zhao, Caiyan2; Wang, Zhen1; Song, Xiang1; Wu, Yan2; Zhao, Lian1; Zhou, Hong1
2017-04-01
发表期刊BIOMACROMOLECULES
ISSN1525-7797
卷号18期号:4页码:1333-1341
摘要

Oxidative side reaction is one of the major factors hindering the development of hemoglobin-based oxygen carriers (HBOCs). To avoid the oxidative toxicity, we designed and synthesized polydopamine-coated hemoglobin (Hb-PDA) nanoparticles via simple one-step assemblage without any toxic reagent. Hb-PDA nanoparticles showed oxidative protection of Hb by inhibiting the generation of methemoglobin (MetHb) and ferryl (Fe IV) Hb, as well as excellent antioxidant properties by scavenging free radicals and reactive oxygen species (ROS). Interestingly, the scavenging rate of Hb-PDA nanoparticles for ABTS(+) radical is at most 89%, while for DPPH radical it reaches 49%. In addition, Hb-PDA efficiently reduced the intracellular H2O2-induced ROS generation. Moreover, Hb-PDA nanoparticles exhibited high oxygen affinity, low effect on blood constituents, and low cytotoxicity. The results indicate that polydopamine-coated hemoglobin might be a promising approach for constructing novel oxygen carriers with the capacity to reduce oxidative side reaction.

文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1021/acs.biomac.7b00077
收录类别SCI
语种英语
关键词[WOS]Red-blood-cells ; Heme Degradation ; Cross-linking ; In-vitro ; Nanoparticles ; Substitutes ; Glutaraldehyde ; Methemoglobin ; Assemblies ; Protection
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
项目资助者National Natural Science Foundation of China(31271001) ; Beijing Natural Science Foundation(2174085)
WOS记录号WOS:000399061100028
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/22846
专题多相复杂系统国家重点实验室
作者单位1.Beijing Inst Transfus Med, Beijing Key Lab Blood Safety & Supply Technol, Beijing 100039, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
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GB/T 7714
Wang, Quan,Zhang, Ruirui,Lu, Mingzi,et al. Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties[J]. BIOMACROMOLECULES,2017,18(4):1333-1341.
APA Wang, Quan.,Zhang, Ruirui.,Lu, Mingzi.,You, Guoxing.,Wang, Ying.,...&Zhou, Hong.(2017).Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties.BIOMACROMOLECULES,18(4),1333-1341.
MLA Wang, Quan,et al."Bioinspired Polydopamine-Coated Hemoglobin as Potential Oxygen Carrier with Antioxidant Properties".BIOMACROMOLECULES 18.4(2017):1333-1341.
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