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A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles
Qu, Hongnan1,2,3,4; Yang, Liangrong2; Yu, Jiemiao2; Dong, Tingting2,3; Rong, Meng2,3; Zhang, Jianfeng2,3,4; Xing, Huifang2; Wang, Li2; Pan, Feng2; Liu, Huizhou2
2017
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume7Issue:57Pages:35704-35710
Abstract

A novel redox responsive controlled release system based on the host-guest interaction between ferrocene modified mesoporous silica nanoparticles (MSN-Fc) and beta-cyclodextrin modified gold nanoparticles (Au@CD) was developed. FITC was used as the release molecule and it was loaded into the pores of MSN-Fc. With the addition of oxidant (H2O2), oxidized ferrocene leaves the hydrophobic cavity of b-CD, resulting in cargo controlled release. Due to the structural properties of the modified MSN, the continuously slow release behavior showed the prospect to be a sustained drug delivery system. This novel redox responsive system possessed stimuli-responsive controlled release and sustained release properties, and therefore has potential applications in sustained and targeted drug delivery.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c7ra04444e
Indexed BySCI
Language英语
WOS KeywordOPERATED MECHANIZED NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; GUEST MOLECULES ; CARGO RELEASE ; IN-VITRO ; PH ; NANOVALVES ; ENZYME ; NANOCARRIERS
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21676273) ; National Key Natural Science Foundation of China(U1507203) ; National Technology Research and Development Program of China(2015CB251402) ; Youth Innovation Promotion Association, CAS(2016043)
WOS IDWOS:000406104300018
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/22982
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Qu, Hongnan,Yang, Liangrong,Yu, Jiemiao,et al. A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles[J]. RSC ADVANCES,2017,7(57):35704-35710.
APA Qu, Hongnan.,Yang, Liangrong.,Yu, Jiemiao.,Dong, Tingting.,Rong, Meng.,...&Liu, Huizhou.(2017).A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles.RSC ADVANCES,7(57),35704-35710.
MLA Qu, Hongnan,et al."A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles".RSC ADVANCES 7.57(2017):35704-35710.
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