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题名:
A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles
作者: Qu, Hongnan1,2,3,4; Yang, Liangrong2; Yu, Jiemiao2; Dong, Tingting2,3; Rong, Meng2,3; Zhang, Jianfeng2,3,4; Xing, Huifang2; Wang, Li2; Pan, Feng2; Liu, Huizhou2
刊名: RSC ADVANCES
出版日期: 2017
卷号: 7, 期号:57, 页码:35704-35710
收录类别: SCI
WOS记录号: WOS:000406104300018
DOI: 10.1039/c7ra04444e
文章类型: Article
英文摘要: A novel redox responsive controlled release system based on the host-guest interaction between ferrocene modified mesoporous silica nanoparticles (MSN-Fc) and beta-cyclodextrin modified gold nanoparticles (Au@CD) was developed. FITC was used as the release molecule and it was loaded into the pores of MSN-Fc. With the addition of oxidant (H2O2), oxidized ferrocene leaves the hydrophobic cavity of b-CD, resulting in cargo controlled release. Due to the structural properties of the modified MSN, the continuously slow release behavior showed the prospect to be a sustained drug delivery system. This novel redox responsive system possessed stimuli-responsive controlled release and sustained release properties, and therefore has potential applications in sustained and targeted drug delivery.
WOS标题词: Science & Technology ; Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: OPERATED MECHANIZED NANOPARTICLES ; DRUG-DELIVERY ; MAGNETIC NANOPARTICLES ; GUEST MOLECULES ; CARGO RELEASE ; IN-VITRO ; PH ; NANOVALVES ; ENZYME ; NANOCARRIERS
项目资助者: National Natural Science Foundation of China(21676273) ; National Key Natural Science Foundation of China(U1507203) ; National Technology Research and Development Program of China(2015CB251402) ; Youth Innovation Promotion Association, CAS(2016043)
语种: 英语
ISSN号: 2046-2069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ipe.ac.cn/handle/122111/22982
Appears in Collections:生化工程国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Sinodanish Ctr Educ & Res, Beijing 100190, Peoples R China

Recommended Citation:
Qu, Hongnan,Yang, Liangrong,Yu, Jiemiao,et al. A redox responsive controlled release system using mesoporous silica nanoparticles capped with Au nanoparticles[J]. RSC ADVANCES,2017,7(57):35704-35710.
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