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Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
Yong, Yuan1,2,5; Zhang, Chunfang3; Gu, Zhanjun1,2,3; Du, Jiangfeng1,2; Guo, Zhao1,2; Dong, Xinghua3; Xie, Jiani1,2; Zhang, Guangjin4; Liu, Xiangfeng3; Zhao, Yuliang1,2,3
2017-07-01
Source PublicationACS NANO
ISSN1936-0851
Volume11Issue:7Pages:7164-7176
Abstract

Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing an ideal radiosensitization system with appreciable radiosensitization capacity to attenuate tumor hypoxia and reinforce radiotherapy response in hypoxic tumors. Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radio sensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-la (HIF-la) siRNA to down-regulate HIF-la expression and suppress broken double-stranded DNA self-healing. Most importantly, the GdW10@CS nanospheres have the capacity to promote the exhaustion of intracellular glutathione (reduced GSH) by synergy W6+-triggered GSH oxidation for sufficient ROS generation, thereby facilitating the therapeutic efficiency of radiotherapy. As a result, the as-synthesized GdW10@CS nanosphere can overcome radioresistance of hypoxic tumors through a simultaneous extrinsic and intrinsic strategy to improve radiosensitivity. We have demonstrated GdW10@CS nanospheres with special radiosensitization behavior, which provides a versatile approach to solve the critical radioresistance issue of hypoxic tumors.

KeywordPolyoxometalates Gdw10@cs Nanosphere Glutathione Radiosensitization Hypoxic Tumor Radiotherapy Gene Therapy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.7b03037
Indexed BySCI
Language英语
WOS KeywordIron-oxide Nanoparticles ; Inducible Factor-i ; Photodynamic Therapy ; Cancer-therapy ; Gold Nanoparticles ; Targeting Hypoxia ; Gene-expression ; Sirna Delivery ; Quantum Dots ; Radiotherapy
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Basic Research Programs of China (973 Programs)(2016YFA0201600 ; National Natural Science Foundation of China(31571015 ; Youth Innovation Promotion Association CAS(2013007) ; 2014CB931900 ; 11621505 ; 2015CB932104) ; 11435002 ; 21320102003)
WOS IDWOS:000406649700066
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23156
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci Technol China, Beijing 100049, Peoples R China
3.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
5.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Yong, Yuan,Zhang, Chunfang,Gu, Zhanjun,et al. Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response[J]. ACS NANO,2017,11(7):7164-7176.
APA Yong, Yuan.,Zhang, Chunfang.,Gu, Zhanjun.,Du, Jiangfeng.,Guo, Zhao.,...&Zhao, Yuliang.(2017).Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.ACS NANO,11(7),7164-7176.
MLA Yong, Yuan,et al."Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response".ACS NANO 11.7(2017):7164-7176.
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