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Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response
Yong, Yuan1,2,5; Zhang, Chunfang3; Gu, Zhanjun1,2,3; Du, Jiangfeng1,2; Guo, Zhao1,2; Dong, Xinghua3; Xie, Jiani1,2; Zhang, Guangjin4; Liu, Xiangfeng3; Zhao, Yuliang1,2,3
2017-07-01
发表期刊ACS NANO
ISSN1936-0851
卷号11期号:7页码:7164-7176
摘要Radioresistance is one of the undesirable impediments in hypoxic tumors, which sharply diminishes the therapeutic effectiveness of radiotherapy and eventually results in the failure of their treatments. An attractive strategy for attenuating radioresistance is developing an ideal radiosensitization system with appreciable radiosensitization capacity to attenuate tumor hypoxia and reinforce radiotherapy response in hypoxic tumors. Therefore, we describe the development of Gd-containing polyoxometalates-conjugated chitosan (GdW10@CS nanosphere) as a radio sensitization system for simultaneous extrinsic and intrinsic radiosensitization, by generating an overabundance of cytotoxic reactive oxygen species (ROS) using high-energy X-ray stimulation and mediating the hypoxia-inducible factor-la (HIF-la) siRNA to down-regulate HIF-la expression and suppress broken double-stranded DNA self-healing. Most importantly, the GdW10@CS nanospheres have the capacity to promote the exhaustion of intracellular glutathione (reduced GSH) by synergy W6+-triggered GSH oxidation for sufficient ROS generation, thereby facilitating the therapeutic efficiency of radiotherapy. As a result, the as-synthesized GdW10@CS nanosphere can overcome radioresistance of hypoxic tumors through a simultaneous extrinsic and intrinsic strategy to improve radiosensitivity. We have demonstrated GdW10@CS nanospheres with special radiosensitization behavior, which provides a versatile approach to solve the critical radioresistance issue of hypoxic tumors.
关键词Polyoxometalates Gdw10@cs Nanosphere Glutathione Radiosensitization Hypoxic Tumor Radiotherapy Gene Therapy
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.7b03037
收录类别SCI
语种英语
关键词[WOS]IRON-OXIDE NANOPARTICLES ; INDUCIBLE FACTOR-I ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; GOLD NANOPARTICLES ; TARGETING HYPOXIA ; GENE-EXPRESSION ; SIRNA DELIVERY ; QUANTUM DOTS ; RADIOTHERAPY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Basic Research Programs of China (973 Programs)(2016YFA0201600 ; National Natural Science Foundation of China(31571015 ; Youth Innovation Promotion Association CAS(2013007) ; 2014CB931900 ; 11621505 ; 2015CB932104) ; 11435002 ; 21320102003)
WOS记录号WOS:000406649700066
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23156
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci Technol China, Beijing 100049, Peoples R China
3.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
5.Southwest Minzu Univ, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China
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Yong, Yuan,Zhang, Chunfang,Gu, Zhanjun,et al. Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response[J]. ACS NANO,2017,11(7):7164-7176.
APA Yong, Yuan.,Zhang, Chunfang.,Gu, Zhanjun.,Du, Jiangfeng.,Guo, Zhao.,...&Zhao, Yuliang.(2017).Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.ACS NANO,11(7),7164-7176.
MLA Yong, Yuan,et al."Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response".ACS NANO 11.7(2017):7164-7176.
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