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MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice
Zhang, Ling-xiao1,2; Liu, Dong-qun1,2; Wang, Shao-wei1; Yu, Xiao-lin1; Ji, Mei1,2; Xie, Xi-xiu1; Liu, Shu-ying1; Liu, Rui-tian1
2017-08-21
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume5Issue:31Pages:6266-6276
Abstract

Active immunotherapy has shown promising potential for cancer treatment. However, there still remain major challenges including induction of a potent and specific T-cell response against the endogenous antigen and retention of tumor immunity. To address these problems, we used layered double hydroxide (LDH) nanoparticles (NPs) to co-deliver tyrosinase-related protein 2 (Trp2) and indoleamine 2,3-dioxygenase siRNA (siIDO) to dendritic cells (DCs). These LDH NPs were readily taken in by DCs, and escaped from endosomes into the cytoplasm. Compared with free Trp2 peptide or siIDO, the vaccination with the LDH NPs co-delivering Trp2 and siIDO significantly inhibited tumor growth in melanoma mouse models by relieving IDO-mediated immune suppression and increasing naive and specific T cell activation process in vivo. Thus, these LDH NPs, which have a high loading capacity for peptide or siRNA effectively protect and deliver Trp2 and siIDO, overcome the immune tolerance and strengthen T cell immunity, are potential therapeutics to enhance cancer treatment.

SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c7tb00819h
Indexed BySCI
Language英语
WOS KeywordAryl-hydrocarbon Receptor ; Cell-based Vaccines ; Virus-dna Vaccine ; Dendritic Cells ; Indoleamine 2,3-dioxygenase ; Alzheimers-disease ; Uptake Mechanism ; Immune-response ; Drug-delivery ; Gene Delivery
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; 81402837) ; 2014ZX09102041-007)
WOS IDWOS:000407337500011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23163
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling-xiao,Liu, Dong-qun,Wang, Shao-wei,et al. MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(31):6266-6276.
APA Zhang, Ling-xiao.,Liu, Dong-qun.,Wang, Shao-wei.,Yu, Xiao-lin.,Ji, Mei.,...&Liu, Rui-tian.(2017).MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice.JOURNAL OF MATERIALS CHEMISTRY B,5(31),6266-6276.
MLA Zhang, Ling-xiao,et al."MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice".JOURNAL OF MATERIALS CHEMISTRY B 5.31(2017):6266-6276.
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