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Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index
Li, Shao-Lu1; Hou, Yingqin1; Hu, Yali1; Yu, Jin1; Wei, Wei2; Lu, Hua1
2017-08-01
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume5Issue:8Pages:1558-1566
Abstract

We describe here the synthesis and cell-selective delivery of a cationic Pt(IV)-backboned prodrug-like polymer P(DSP-DAEP). P(DSP-DAEP) features excellent aqueous solubility, unusually high (44.5%) drug loading, can be rapidly reduced to release the active cisplatin, and is more potent than its small molecular Pt(IV) precursor DSP. P(DSP-DAEP) can be formulated with an oppositely charged methoxyl poly(ethylene glycol)-block-poly(L-phosphotyrosine) (mPEG-b-PpY) to afford a polyion micelle (Pt-PIC) by taking advantage of polyelectrolyte coacervation. Preliminary in vitro cellular uptake and cytotoxicity assays indicate that Pt-PIC exhibits receptor (surface alkaline phosphatase)-dependent uptake and cytotoxicity. Overall, our results suggest a new approach to the improved therapeutic index of platinum-based anticancer drugs via cell-selective delivery.

SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c6bm00935b
Indexed BySCI
Language英语
WOS KeywordNanoscale Coordination Polymers ; Anticancer Drug-delivery ; Plga-peg Nanoparticles ; Pt(Iv) Pro-drug ; Cancer-therapy ; Co-delivery ; Antitumor Efficacy ; Cisplatin Prodrug ; Targeted Delivery ; Platinum Drugs
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationNational Key Research and Development Program of China(2016YFA0201400) ; National Natural Science Foundation of China(NSFC21434008) ; Open Funding Project of the State Key Laboratory of Biochemical Engineering(2015KF-01) ; China Postdoctoral Science Foundation(2016 M600847) ; Postdoctoral Fellowship of the Peking-Tsinghua Center for Life Sciences
WOS IDWOS:000406321700021
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23166
Collection生化工程国家重点实验室
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn,Coll Chem & Mol Engn, Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 10090, Peoples R China
Recommended Citation
GB/T 7714
Li, Shao-Lu,Hou, Yingqin,Hu, Yali,et al. Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index[J]. BIOMATERIALS SCIENCE,2017,5(8):1558-1566.
APA Li, Shao-Lu,Hou, Yingqin,Hu, Yali,Yu, Jin,Wei, Wei,&Lu, Hua.(2017).Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index.BIOMATERIALS SCIENCE,5(8),1558-1566.
MLA Li, Shao-Lu,et al."Phosphatase-triggered cell-selective release of a Pt(IV)-backboned prodrug-like polymer for an improved therapeutic index".BIOMATERIALS SCIENCE 5.8(2017):1558-1566.
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