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The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide
Xu, Qingsong1,2; Liu, Meisi1; Liu, Qishun1; Wang, Wenxia1; Du, Yuguang3; Yin, Heng1
2017-10-15
发表期刊CARBOHYDRATE POLYMERS
ISSN0144-8617
卷号174期号:OCT页码:1138-1143
摘要

Chitooligosaccharide (COS) has been shown to regulate many biological functions, such as antimicrobial effect and antitumor activity. In the present study, highly N-acetylated chitooligosaccharide(NACOS) was prepared by N-acetylation of COS, and the anti-inflammatory activity of NACOS in macrophages were evaluated. The results indicated NACOS significantly suppressed the LPS-induced proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha) expression. Furthermore, the increased levels of reactive oxygen species (ROS) and nitric oxide (NO) were repressed by NACOS in a dose dependent manner. However, NACOS itself had no significant effect on the cell viability and cellular morphology. Signal transduction studies demonstrated that NACOS remarkably inhibited LPS-enhanced phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt. These findings provide a possible molecular mechanism by which NACOS inhibit LPS-induced inflammatory response in macrophages, and a basis for utilizing NACOS in pharmaceutical therapy against inflammation. (C) 2017 Elsevier Ltd. All rights reserved.

关键词N-acetylated Chitooligosaccharide Lipopolysaccharides Interleukin-6 Tumor Necrosis Factor-alpha Inflammation Pi3k/akt Pathway
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2017.07.051
收录类别SCI
语种英语
关键词[WOS]RAW 264.7 CELLS ; CHITOSAN OLIGOSACCHARIDES ; IN-VITRO ; ENDOTHELIAL-CELLS ; MOLECULAR-WEIGHT ; CHITIN ; EXPRESSION ; MICROGLIA ; DISEASES ; VIVO
WOS研究方向Chemistry ; Polymer Science
WOS类目Chemistry, Applied ; Chemistry, Organic ; Polymer Science
项目资助者Ocean Public Welfare Scientific Research Project, State Oceanic Administration of China(201405003) ; National High Technology Research and Development Program of China (863 Program)(2014AA093604)
WOS记录号WOS:000407696800119
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23219
专题研究所(批量导入)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
2.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
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GB/T 7714
Xu, Qingsong,Liu, Meisi,Liu, Qishun,et al. The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide[J]. CARBOHYDRATE POLYMERS,2017,174(OCT):1138-1143.
APA Xu, Qingsong,Liu, Meisi,Liu, Qishun,Wang, Wenxia,Du, Yuguang,&Yin, Heng.(2017).The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide.CARBOHYDRATE POLYMERS,174(OCT),1138-1143.
MLA Xu, Qingsong,et al."The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide".CARBOHYDRATE POLYMERS 174.OCT(2017):1138-1143.
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