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Aggregation-Induced-Emission Materials with Different Electric Charges as an Artificial Tongue: Design, Construction, and Assembly with Various Pathogenic Bacteria for Effective Bacterial Imaging and Discrimination
Liu, Guang-jian1; Tian, Sheng-nan2,3; Li, Cui-yun1; Xing, Guo-wen2; Zhou, Lei2,3
2017-08-30
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:34Pages:28331-28338
Abstract

Imaging-based total bacterial count and type identification of bacteria play crucial roles in clinical diagnostics; public health, biological and medical science, and environmental protection. Herein, we designed and synthesized a series of tetraphenylethenes (TPEs) functionalized with one or two aldehyde, carboxylic acid, and quaternary ammonium groups, which were successfully used as fluorescent materials for rapid and efficient staining of eight kinds of reptesentative bacterial species, including pathogenic bacteria Vibrio cholera, Klebsiella pneumoniae, and Listeria monocytogenes and potential bioterrorism agent Yersinia pestis. By comparing the fluorescence intensity changes of the aggregation-induced-erinssion (AIE) materials before and after bacteria incubation, the sensing mechanisms (electrostatic versus hydrophobic interactions) were simply discussed. Moreover, the designed AIE materials were successfully used as an efficient artificial tongue for bacteria discrimination, and all of the bacteria tested were identified via linear discriminant analysis. Our current work provided a general method for simultaneous broad-spectrum bacterial imaging and species discrimination, which is helpful for bacteria surveillance in many fields.

KeywordTetraphenylethene Aggregation-induced Emission Linear Discrimination Analysis Bacterial Imaging Bacterial Discrimination
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acsami.7b09848
Indexed BySCI
Language英语
WOS KeywordMicrobial Pathogens ; Aie Luminogen ; Sensor Arrays ; Living Cells ; Fluorescent ; Identification ; Probe ; Polymers ; Assay ; Wall
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21272027) ; National Key Research and Development Program of China(2016YFC1202502) ; National High Technology Research and Development Program of China (863 Program)(2013AA032205) ; Beijing Nova Program of China(Z151100000315086)
WOS IDWOS:000409395500021
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23231
Collection生化工程国家重点实验室
Affiliation1.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
Recommended Citation
GB/T 7714
Liu, Guang-jian,Tian, Sheng-nan,Li, Cui-yun,et al. Aggregation-Induced-Emission Materials with Different Electric Charges as an Artificial Tongue: Design, Construction, and Assembly with Various Pathogenic Bacteria for Effective Bacterial Imaging and Discrimination[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(34):28331-28338.
APA Liu, Guang-jian,Tian, Sheng-nan,Li, Cui-yun,Xing, Guo-wen,&Zhou, Lei.(2017).Aggregation-Induced-Emission Materials with Different Electric Charges as an Artificial Tongue: Design, Construction, and Assembly with Various Pathogenic Bacteria for Effective Bacterial Imaging and Discrimination.ACS APPLIED MATERIALS & INTERFACES,9(34),28331-28338.
MLA Liu, Guang-jian,et al."Aggregation-Induced-Emission Materials with Different Electric Charges as an Artificial Tongue: Design, Construction, and Assembly with Various Pathogenic Bacteria for Effective Bacterial Imaging and Discrimination".ACS APPLIED MATERIALS & INTERFACES 9.34(2017):28331-28338.
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