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Oxidation of beta-lactam antibiotics by peracetic acid: Reaction kinetics, product and pathway evaluation
Zhang, Kejia1,2; Zhou, Xinyan1; Du, Penghui2,3; Zhang, Tuqiao1; Cai, Meiquan2,4; Sun, Peizhe2,5; Huang, Ching-Hua2
2017-10-15
发表期刊WATER RESEARCH
ISSN0043-1354
卷号123页码:153-161
摘要

Peracetic acid (PAA) is a disinfection oxidant used in many industries including wastewater treatment. beta-Lactams, a group of widely prescribed antibiotics, are frequently detected in wastewater effluents and surface waters. The reaction kinetics and transformation of seven beta-lactams (cefalexin (CFX), cefadroxil (CFR), cefapirin (CFP), cephalothin (CFT), ampicillin (AMP), amoxicillin (AMX) and penicillin G (PG)) toward PM were investigated to elucidate the behavior of beta-lactams during PAA oxidation processes. The reaction follows second-order kinetics and is much faster at pH 5 and 7 than at pH 9 due to speciation of PM. Reactivity to PAA follows the order of CFR similar to CFX > AMP similar to AMX > CFT CFP similar to PG and is related to beta-lactam's nucleophilicity. The thioether sulfur of beta-lactams is attacked by PAA to generate sulfoxide products. Presence of the phenylglycinyl amino group on beta-lactams can significantly influence electron distribution and the highest occupied molecular orbital (HOMO) location and energy in ways that enhance the reactivity to PM. Reaction rate constants obtained in clean water matrix can be used to accurately model the decay of beta-lactams by PM in surface water matrix and only slightly overestimate the decay in wastewater matrix. Results of this study indicate that the oxidative transformation of beta-lactams by PM can be expected under appropriate wastewater treatment conditions. 2017 Published by Elsevier Ltd.

关键词Peracetic Acid Penicillins Cephalosporins Emerging Contaminants Wastewater Treatment Oxidation
文章类型Article
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1016/j.watres.2017.06.057
收录类别SCI
语种英语
关键词[WOS]Municipal Waste-water ; By-products ; Disinfection ; Pharmaceuticals ; Ozonation ; Effluent ; Removal ; Uv ; Transformation ; Decomposition
WOS研究方向Engineering ; Environmental Sciences & Ecology ; Water Resources
WOS类目Engineering, Environmental ; Environmental Sciences ; Water Resources
项目资助者National Research Council of Science and Technology Major Project of China (Water Pollution Control and Treatment)(2012ZX07403-003) ; Natural Science Foundation of Zhejiang Province(LY17E080014) ; Fundamental Research Funds for the Central Universities(2016FZA4017) ; U.S. National Science Foundation(CHE-1609361)
WOS记录号WOS:000410010500016
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23233
专题研究所(批量导入)
作者单位1.Zhejiang Univ, Coll Civil Engn & Architecture, Hangzhou 310058, Zhejiang, Peoples R China
2.Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
4.Tsinghua Univ, Sch Environm, Beijing 100084, Peoples R China
5.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China
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GB/T 7714
Zhang, Kejia,Zhou, Xinyan,Du, Penghui,et al. Oxidation of beta-lactam antibiotics by peracetic acid: Reaction kinetics, product and pathway evaluation[J]. WATER RESEARCH,2017,123:153-161.
APA Zhang, Kejia.,Zhou, Xinyan.,Du, Penghui.,Zhang, Tuqiao.,Cai, Meiquan.,...&Huang, Ching-Hua.(2017).Oxidation of beta-lactam antibiotics by peracetic acid: Reaction kinetics, product and pathway evaluation.WATER RESEARCH,123,153-161.
MLA Zhang, Kejia,et al."Oxidation of beta-lactam antibiotics by peracetic acid: Reaction kinetics, product and pathway evaluation".WATER RESEARCH 123(2017):153-161.
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