CAS OpenIR  > 研究所(批量导入)
Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate: cation-base clusters vs. anion-acid dimers
Berton, Paula1; Kelley, Steven P.1; Wang, Hui2; Myerson, Allan S.3,4; Rogers, Robin D.1,5
2017-10-07
发表期刊PHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN1463-9076
卷号19期号:37页码:25544-25554
摘要

We investigated the ability of the ions comprising protic ionic liquids to strongly interact with their neutral acid and base forms through the characterization of n-butylammonium acetate ([C4NH3][OAc]) in the presence of excess n-butylamine (C4NH2) or excess acetic acid (HOAc). The conjugate and parent acid or base form new nonstoichiometric, noncovalently bound species (i.e., oligomeric ions) which change the physical and chemical properties of the resulting liquids, thus offering tunability. The effects of adding C4NH2 or HOAc to [C4NH3][OAc] on the resulting thermal and spectroscopic properties differ and suggest that C4NH2 interacts primarily with [C4NH3](+) to form 3-dimensional polymeric networks likely similar to those in H2O/[H3O](+),while HOAc interacts primarily with [OAc](-) to form oligomeric ions (e.g., [H(OAc)(2)](-)). The densities of the systems increased with the increase of acid content and reached a maximum when the acid molar fraction was 0.90, but decreased with increasing amine concentration. The viscosities decreased significantly with increasing acid or base concentration. The solvent properties of the mixtures were assessed by measuring the solubilities of benzene, ethyl acetate, diethyl ether, heptane, ibuprofen free acid, and lidocaine free base. The solubilities of the organic solutes and active pharmaceutical ingredients can be tuned with the concentration of acid or amine in the mixtures. In addition, crystallization of the active pharmaceutical ingredients can be induced with the modification of the composition of the mixtures. These observations support the usage of these mixtures for the synthesis and purification of acid or basic active pharmaceutical ingredients in the pharmaceutical industry.

文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c7cp04078d
收录类别SCI
语种英语
关键词[WOS]Binary-mixtures ; Physical-properties ; Aqueous-solutions ; Liquid-mixtures ; Salts ; Solubility ; Ionicity ; Water ; n,N-dimethylformamide ; Conductivity
WOS研究方向Chemistry ; Physics
WOS类目Chemistry, Physical ; Physics, Atomic, Molecular & Chemical
项目资助者Novartis-Massachusetts Institute of Technology (MIT) Center for Continuous Manufacturing (CCM) ; Novartis International AG ; Canada Excellence Research Chairs Program
WOS记录号WOS:000412271600033
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23252
专题研究所(批量导入)
作者单位1.McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada
2.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
3.MIT, Novartis MIT Ctr Continuous Mfg, 77 Massachusetts Ave, Cambridge, MA 02139 USA
4.MIT, Dept Chem Engn, Cambridge, MA 02139 USA
5.525 Solut Inc, 720 2nd St, Tuscaloosa, AL 35401 USA
推荐引用方式
GB/T 7714
Berton, Paula,Kelley, Steven P.,Wang, Hui,et al. Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate: cation-base clusters vs. anion-acid dimers[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2017,19(37):25544-25554.
APA Berton, Paula,Kelley, Steven P.,Wang, Hui,Myerson, Allan S.,&Rogers, Robin D..(2017).Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate: cation-base clusters vs. anion-acid dimers.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,19(37),25544-25554.
MLA Berton, Paula,et al."Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate: cation-base clusters vs. anion-acid dimers".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 19.37(2017):25544-25554.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Separate mechanisms (2916KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Berton, Paula]的文章
[Kelley, Steven P.]的文章
[Wang, Hui]的文章
百度学术
百度学术中相似的文章
[Berton, Paula]的文章
[Kelley, Steven P.]的文章
[Wang, Hui]的文章
必应学术
必应学术中相似的文章
[Berton, Paula]的文章
[Kelley, Steven P.]的文章
[Wang, Hui]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Separate mechanisms of ion oligomerization tune the physicochemical properties of n-butylammonium acetate_ cation-base clusters vs. anion-acid dimers.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。