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Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages
Chen, Jingli1,2; Yang, Jun1; Liu, Ruiyuan1; Qiao, Chenmeng1; Lu, Zhiguo1; Shi, Yuanjie1; Fan, Zhanming3; Zhang, Zhenzhong2; Zhang, Xin1
2017
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume7Issue:17Pages:4149-4167
Abstract

Currently unsatisfactory treatment of myocardial infarction (MI) is due to the unbridled inflammation and the delayed diagnosis at the early stage. To address these problems, firstly, phosphatidylserine (PS) was used to modulate the phenotypes of macrophages (MF) and resolve the early inflammation via binding to PS receptors (PSR) on macrophage surface. Secondly, highly-sensitive magnetic iron oxide nanocubes (MIONs) were adopted to realize the early visualization via magnetic resonance imaging (MRI). However, the major drawback for MIONs as contrast agents was their hydrophobic properties and insufficient delivery. Hence, zwitterionic biodegradable copolymer poly(lactide)polycarboxybetaine (PLA-PCB, PP), companied with PS, was used to provide a good colloidal stability and long blood circulation for the nanocubes. Given the above, a theranostic nanosystem (PP/PS@MIONs) was constructed for early treatment of MI. With external magnetic field-induced targeting and PS targeting, the nanosystem enhanced the accumulation in infarcted area, and accelerated the resolution of early inflammatory responses. Moreover, the nanocubes in system were promoted to escape from endosomes/lysosomes via protonation of PCB, which contributes to accurate MRI. This nanosystem showed good inflammation-resolving effects and imaging ability in MI model rats. Therefore, this theranostic nanosystem can realize accurate visualization and significantly improve the treatment efficacy of MI at early stage.

KeywordMyocardial Infarction Theranostic System Inflammation Regulation Mimicking Apoptosis Magnetic Resonance Imaging
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.21040
Indexed BySCI
Language英语
WOS KeywordIron-oxide Nanoparticles ; Heart-failure ; Magnetic Nanoparticles ; Tnf-alpha ; Cells ; Phosphatidylserine ; Inflammation ; Injury ; Recognition ; Therapy
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
Funding OrganizationNational High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51573188 ; Beijing Municipal Science & Technology Commission(Z161100002616015)
WOS IDWOS:000412296800006
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23256
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China
3.Capital Med Univ, Beijing An Zhen Hosp, Dept Radiol, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Chen, Jingli,Yang, Jun,Liu, Ruiyuan,et al. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages[J]. THERANOSTICS,2017,7(17):4149-4167.
APA Chen, Jingli.,Yang, Jun.,Liu, Ruiyuan.,Qiao, Chenmeng.,Lu, Zhiguo.,...&Zhang, Xin.(2017).Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages.THERANOSTICS,7(17),4149-4167.
MLA Chen, Jingli,et al."Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages".THERANOSTICS 7.17(2017):4149-4167.
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