CAS OpenIR  > 生化工程国家重点实验室
Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages
Chen, Jingli1,2; Yang, Jun1; Liu, Ruiyuan1; Qiao, Chenmeng1; Lu, Zhiguo1; Shi, Yuanjie1; Fan, Zhanming3; Zhang, Zhenzhong2; Zhang, Xin1
2017
发表期刊THERANOSTICS
ISSN1838-7640
卷号7期号:17页码:4149-4167
摘要Currently unsatisfactory treatment of myocardial infarction (MI) is due to the unbridled inflammation and the delayed diagnosis at the early stage. To address these problems, firstly, phosphatidylserine (PS) was used to modulate the phenotypes of macrophages (MF) and resolve the early inflammation via binding to PS receptors (PSR) on macrophage surface. Secondly, highly-sensitive magnetic iron oxide nanocubes (MIONs) were adopted to realize the early visualization via magnetic resonance imaging (MRI). However, the major drawback for MIONs as contrast agents was their hydrophobic properties and insufficient delivery. Hence, zwitterionic biodegradable copolymer poly(lactide)polycarboxybetaine (PLA-PCB, PP), companied with PS, was used to provide a good colloidal stability and long blood circulation for the nanocubes. Given the above, a theranostic nanosystem (PP/PS@MIONs) was constructed for early treatment of MI. With external magnetic field-induced targeting and PS targeting, the nanosystem enhanced the accumulation in infarcted area, and accelerated the resolution of early inflammatory responses. Moreover, the nanocubes in system were promoted to escape from endosomes/lysosomes via protonation of PCB, which contributes to accurate MRI. This nanosystem showed good inflammation-resolving effects and imaging ability in MI model rats. Therefore, this theranostic nanosystem can realize accurate visualization and significantly improve the treatment efficacy of MI at early stage.
关键词Myocardial Infarction Theranostic System Inflammation Regulation Mimicking Apoptosis Magnetic Resonance Imaging
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.21040
收录类别SCI
语种英语
关键词[WOS]IRON-OXIDE NANOPARTICLES ; HEART-FAILURE ; MAGNETIC NANOPARTICLES ; TNF-ALPHA ; CELLS ; PHOSPHATIDYLSERINE ; INFLAMMATION ; INJURY ; RECOGNITION ; THERAPY
WOS研究方向Research & Experimental Medicine
WOS类目Medicine, Research & Experimental
项目资助者National High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51573188 ; Beijing Municipal Science & Technology Commission(Z161100002616015) ; "Strategic Priority Research Program" of the Chinese Academy of Sciences(XDA09030301-3) ; 51373177 ; 31522023)
WOS记录号WOS:000412296800006
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23256
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China
3.Capital Med Univ, Beijing An Zhen Hosp, Dept Radiol, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jingli,Yang, Jun,Liu, Ruiyuan,et al. Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages[J]. THERANOSTICS,2017,7(17):4149-4167.
APA Chen, Jingli.,Yang, Jun.,Liu, Ruiyuan.,Qiao, Chenmeng.,Lu, Zhiguo.,...&Zhang, Xin.(2017).Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages.THERANOSTICS,7(17),4149-4167.
MLA Chen, Jingli,et al."Dual-targeting Theranostic System with Mimicking Apoptosis to Promote Myocardial Infarction Repair via Modulation of Macrophages".THERANOSTICS 7.17(2017):4149-4167.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Jingli]的文章
[Yang, Jun]的文章
[Liu, Ruiyuan]的文章
百度学术
百度学术中相似的文章
[Chen, Jingli]的文章
[Yang, Jun]的文章
[Liu, Ruiyuan]的文章
必应学术
必应学术中相似的文章
[Chen, Jingli]的文章
[Yang, Jun]的文章
[Liu, Ruiyuan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。