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Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
Wei, Yuping1; Ma, Liang2; Zhang, Liang1,2; Xu, Xia2
2017
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume12Pages:7039-7051
Abstract

An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and the CPP may allow fast release of PTX within cells due to the direct translocation of CPP/PTX. This drug delivery system exhibits strong capacity for inhibition of tumor growth and offers a new avenue for the development of advanced drug delivery systems for anticancer therapy.

KeywordPaclitaxel Drug Delivery Cell Penetrating Peptide Anticancer Therapy Molecular Simulations
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.2147/IJN.S144322
Indexed BySCI
Language英语
WOS KeywordCell-penetrating Peptides ; In-vivo ; Polymeric Micelles ; Nanoparticle Formulation ; Tissue Distribution ; Mitotic Block ; Efficacy ; Protein ; Prodrug ; Binding
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China(21506230 ; 21576266)
WOS IDWOS:000411617200002
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23258
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.Anhui Univ Technol, Sch Chem & Chem Engn, Maxianglu St, Maanshan 243032, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yuping,Ma, Liang,Zhang, Liang,et al. Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:7039-7051.
APA Wei, Yuping,Ma, Liang,Zhang, Liang,&Xu, Xia.(2017).Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,7039-7051.
MLA Wei, Yuping,et al."Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):7039-7051.
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