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Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy
Wei, Yuping1; Ma, Liang2; Zhang, Liang1,2; Xu, Xia2
2017
发表期刊INTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
卷号12页码:7039-7051
摘要An effective drug delivery system requires efficient drug uptake and release inside cancer cells. Here, we report a novel drug delivery system, in which paclitaxel (PTX) interacts with a novel cell penetrating peptide (CPP) through noncovalent interaction designed based on molecular simulations. This CPP/PTX complex confers high efficiency in delivering PTX into cancer cells not by endocytosis but by an energy-independent pathway. Once inside cells, the noncovalent interaction between PTX and the CPP may allow fast release of PTX within cells due to the direct translocation of CPP/PTX. This drug delivery system exhibits strong capacity for inhibition of tumor growth and offers a new avenue for the development of advanced drug delivery systems for anticancer therapy.
关键词Paclitaxel Drug Delivery Cell Penetrating Peptide Anticancer Therapy Molecular Simulations
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.2147/IJN.S144322
收录类别SCI
语种英语
关键词[WOS]CELL-PENETRATING PEPTIDES ; IN-VIVO ; POLYMERIC MICELLES ; NANOPARTICLE FORMULATION ; TISSUE DISTRIBUTION ; MITOTIC BLOCK ; EFFICACY ; PROTEIN ; PRODRUG ; BINDING
WOS研究方向Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS类目Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
项目资助者National Natural Science Foundation of China(21506230 ; 21576266)
WOS记录号WOS:000411617200002
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23258
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.Anhui Univ Technol, Sch Chem & Chem Engn, Maxianglu St, Maanshan 243032, Anhui, Peoples R China
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Wei, Yuping,Ma, Liang,Zhang, Liang,et al. Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:7039-7051.
APA Wei, Yuping,Ma, Liang,Zhang, Liang,&Xu, Xia.(2017).Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,7039-7051.
MLA Wei, Yuping,et al."Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):7039-7051.
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