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Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth
Wei, Yuping1; Zhang, Liang1; Fu, Yankai1,2; Xu, Xia3
2017-10-07
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume5Issue:37Pages:7768-7774
Abstract

Paclitaxel (PTX) is widely used to treat ovarian, breast, lung, pancreatic, cervical and other cancers, however, the cell uptake and utilization of PTX is greatly limited by its slow penetration rate and poor solubility in water. Therefore, it is of great interest to develop an efficient method for PTX delivery to improve its cellular uptake and utilization. A novel cell penetrating peptide, RRRRRWW (R7), is developed to accelerate the translocation of PTX into HeLa cells in the organic solvent-free system to suppress tumor growth. There is no significant cytotoxicity induced by the peptide alone even after 24 h incubation at 1 mM at 37 degrees C for both cancer cells and normal cells. In contrast, 30 min treatment with the R7/PTX complex leads to a significant decrease in the cell viability. The intracellular PTX concentration of the R7/PTX complex group is 3 fold that of the free PTX group. The in vivo animal experiments show that the tumor is dramatically suppressed by a tail vein injection of the R7/PTX complex. This system provides a novel approach for the delivery of PTX into tumor cells to efficiently suppress tumor growth.

SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c7tb01259d
Indexed BySCI
Language英语
WOS KeywordIntracellular Fate ; Liposomes ; Cancer ; Binding ; Protein ; Cytotoxicity ; Transporters ; Expression ; Docetaxel ; Complexes
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
Funding OrganizationChinese Academy of Sciences ; National Natural Science Foundation of China(21506230 ; 21576266)
WOS IDWOS:000411863300009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23266
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243032, Anhui, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yuping,Zhang, Liang,Fu, Yankai,et al. Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(37):7768-7774.
APA Wei, Yuping,Zhang, Liang,Fu, Yankai,&Xu, Xia.(2017).Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth.JOURNAL OF MATERIALS CHEMISTRY B,5(37),7768-7774.
MLA Wei, Yuping,et al."Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth".JOURNAL OF MATERIALS CHEMISTRY B 5.37(2017):7768-7774.
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