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Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth
Wei, Yuping1; Zhang, Liang1; Fu, Yankai1,2; Xu, Xia3
2017-10-07
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
卷号5期号:37页码:7768-7774
摘要

Paclitaxel (PTX) is widely used to treat ovarian, breast, lung, pancreatic, cervical and other cancers, however, the cell uptake and utilization of PTX is greatly limited by its slow penetration rate and poor solubility in water. Therefore, it is of great interest to develop an efficient method for PTX delivery to improve its cellular uptake and utilization. A novel cell penetrating peptide, RRRRRWW (R7), is developed to accelerate the translocation of PTX into HeLa cells in the organic solvent-free system to suppress tumor growth. There is no significant cytotoxicity induced by the peptide alone even after 24 h incubation at 1 mM at 37 degrees C for both cancer cells and normal cells. In contrast, 30 min treatment with the R7/PTX complex leads to a significant decrease in the cell viability. The intracellular PTX concentration of the R7/PTX complex group is 3 fold that of the free PTX group. The in vivo animal experiments show that the tumor is dramatically suppressed by a tail vein injection of the R7/PTX complex. This system provides a novel approach for the delivery of PTX into tumor cells to efficiently suppress tumor growth.

文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1039/c7tb01259d
收录类别SCI
语种英语
关键词[WOS]Intracellular Fate ; Liposomes ; Cancer ; Binding ; Protein ; Cytotoxicity ; Transporters ; Expression ; Docetaxel ; Complexes
WOS研究方向Materials Science
WOS类目Materials Science, bioMaterials
项目资助者Chinese Academy of Sciences ; National Natural Science Foundation of China(21506230 ; 21576266)
WOS记录号WOS:000411863300009
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23266
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243032, Anhui, Peoples R China
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GB/T 7714
Wei, Yuping,Zhang, Liang,Fu, Yankai,et al. Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(37):7768-7774.
APA Wei, Yuping,Zhang, Liang,Fu, Yankai,&Xu, Xia.(2017).Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth.JOURNAL OF MATERIALS CHEMISTRY B,5(37),7768-7774.
MLA Wei, Yuping,et al."Rapid delivery of paclitaxel with an organic solvent-free system based on a novel cell penetrating peptide for suppression of tumor growth".JOURNAL OF MATERIALS CHEMISTRY B 5.37(2017):7768-7774.
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