CAS OpenIR  > 生化工程国家重点实验室
PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice
Huang, Na1,2; Lu, Shuai1; Liu, Xiao-Ge1,3; Zhu, Jie1; Wang, Yu-Jiong2; Liu, Rui-Tian1
2017-10-06
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:46Pages:81001-81013
Abstract

Alzheimer's disease (AD) is the most common form of dementia, characterized by the formation of extracellular senile plaques and neuronal loss caused by amyloid beta (A beta) aggregates in the brains of AD patients. Conventional strategies failed to treat AD in clinical trials, partly due to the poor solubility, low bioavailability and ineffectiveness of the tested drugs to cross the blood-brain barrier (BBB). Moreover, AD is a complex, multifactorial neurodegenerative disease; one-target strategies may be insufficient to prevent the processes of AD. Here, we designed novel kind of poly(lactide-co-glycolic acid) (PLGA) nanoparticles by loading with A beta generation inhibitor S1 (PQVGHL peptide) and curcumin to target the detrimental factors in AD development and by conjugating with brain targeting peptide CRT (cyclic CRTIGPSVC peptide), an iron-mimic peptide that targets transferrin receptor (TfR), to improve BBB penetration. The average particle size of drug-loaded PLGA nanoparticles and CRT-conjugated PLGA nanoparticles were 128.6 nm and 139.8 nm, respectively. The results of Y-maze and new object recognition test demonstrated that our PLGA nanoparticles significantly improved the spatial memory and recognition in transgenic AD mice. Moreover, PLGA nanoparticles remarkably decreased the level of A beta, reactive oxygen species (ROS), TNF-alpha and IL-6, and enhanced the activities of super oxide dismutase (SOD) and synapse numbers in the AD mouse brains. Compared with other PLGA nanoparticles, CRT peptide modified-PLGA nanoparticles co-delivering S1 and curcumin exhibited most beneficial effect on the treatment of AD mice, suggesting that conjugated CRT peptide, and encapsulated S1 and curcumin exerted their corresponding functions for the treatment.

KeywordAlzheimer's Disease Nanoparticles Beta-amyloid Curcumin Peptide
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.20944
Indexed BySCI
Language英语
WOS KeywordBlood-brain-barrier ; Protein-cleaving Enzyme ; Drug-delivery ; Neurodegenerative Diseases ; Mouse Model ; Bace1 ; Secretase ; Encapsulation ; Neurogenesis ; Glioblastoma
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
Funding OrganizationNational Natural Science Foundation of China(31401158) ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-006) ; State Key Laboratory of Biochemical Engineering(2015KF-02)
WOS IDWOS:000412465700078
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23276
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Ningxia Univ, Key Lab Minist Educ Protect & Utilizat Special Bi, Yinchuan 750021, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Na,Lu, Shuai,Liu, Xiao-Ge,et al. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice[J]. ONCOTARGET,2017,8(46):81001-81013.
APA Huang, Na,Lu, Shuai,Liu, Xiao-Ge,Zhu, Jie,Wang, Yu-Jiong,&Liu, Rui-Tian.(2017).PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice.ONCOTARGET,8(46),81001-81013.
MLA Huang, Na,et al."PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice".ONCOTARGET 8.46(2017):81001-81013.
Files in This Item:
File Name/Size DocType Version Access License
PLGA nanoparticles m(2798KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Na]'s Articles
[Lu, Shuai]'s Articles
[Liu, Xiao-Ge]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Na]'s Articles
[Lu, Shuai]'s Articles
[Liu, Xiao-Ge]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Na]'s Articles
[Lu, Shuai]'s Articles
[Liu, Xiao-Ge]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.