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Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy
Liu, Yanlan1,2; Ji, Xiaoyuan1,2,3,4; Liu, Jianhua5; Tong, Winnie W. L.1,2; Askhatova, Diana1,2; Shi, Jinjun1,2
2017-10-19
发表期刊ADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
卷号27期号:39页码:1703261
摘要

Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications. However, Ta-based nanomaterials by themselves have not been explored for NIR-mediated photothermal ablation therapy. In this work, an innovative Ta-based multifunctional nanoplatform composed of biocompatible tantalum sulfide (TaS2) nanosheets (NSs) is reported for simultaneous NIR hyperthermia, drug delivery, and computed tomography (CT) imaging. The TaS2 NSs exhibit multiple unique features including (i) efficient NIR light-to-heat conversion with a high photothermal conversion efficiency of 39%, (ii) high drug loading (177% by weight), (iii) controlled drug release triggered by NIR light and moderate acidic pH, (iv) high tumor accumulation via heat-enhanced tumor vascular permeability, (v) complete tumor ablation and negligible side effects, and (vi) comparable CT imaging contrast efficiency to the widely clinically used agent iobitridol. It is expected that this multifunctional NS platform can serve as a promising candidate for imaging-guided cancer therapy and selection of cancer patients with high tumor accumulation.

关键词Cancer Therapy Ct Imaging Drug Delivery Hyperthermia Tas2 Nanosheets
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201703261
收录类别SCI
语种英语
关键词[WOS]TRIGGERED DRUG-DELIVERY ; CANCER-THERAPY ; IN-VIVO ; SOLID TUMORS ; NANOPARTICLES ; FACILE ; AGENT ; NANOMEDICINES ; NANOMATERIALS ; HYPERTHERMIA
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者NIH(CA200900 ; Prostate Cancer Foundation Young Investigator Award ; CA160350)
WOS记录号WOS:000413166400014
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23293
专题生化工程国家重点实验室
作者单位1.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China
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GB/T 7714
Liu, Yanlan,Ji, Xiaoyuan,Liu, Jianhua,et al. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(39):1703261.
APA Liu, Yanlan,Ji, Xiaoyuan,Liu, Jianhua,Tong, Winnie W. L.,Askhatova, Diana,&Shi, Jinjun.(2017).Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy.ADVANCED FUNCTIONAL MATERIALS,27(39),1703261.
MLA Liu, Yanlan,et al."Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy".ADVANCED FUNCTIONAL MATERIALS 27.39(2017):1703261.
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