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Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy
Liu, Yanlan1,2; Ji, Xiaoyuan1,2,3,4; Liu, Jianhua5; Tong, Winnie W. L.1,2; Askhatova, Diana1,2; Shi, Jinjun1,2
2017-10-19
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume27Issue:39Pages:1703261
Abstract

Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications. However, Ta-based nanomaterials by themselves have not been explored for NIR-mediated photothermal ablation therapy. In this work, an innovative Ta-based multifunctional nanoplatform composed of biocompatible tantalum sulfide (TaS2) nanosheets (NSs) is reported for simultaneous NIR hyperthermia, drug delivery, and computed tomography (CT) imaging. The TaS2 NSs exhibit multiple unique features including (i) efficient NIR light-to-heat conversion with a high photothermal conversion efficiency of 39%, (ii) high drug loading (177% by weight), (iii) controlled drug release triggered by NIR light and moderate acidic pH, (iv) high tumor accumulation via heat-enhanced tumor vascular permeability, (v) complete tumor ablation and negligible side effects, and (vi) comparable CT imaging contrast efficiency to the widely clinically used agent iobitridol. It is expected that this multifunctional NS platform can serve as a promising candidate for imaging-guided cancer therapy and selection of cancer patients with high tumor accumulation.

KeywordCancer Therapy Ct Imaging Drug Delivery Hyperthermia Tas2 Nanosheets
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201703261
Indexed BySCI
Language英语
WOS KeywordTRIGGERED DRUG-DELIVERY ; CANCER-THERAPY ; IN-VIVO ; SOLID TUMORS ; NANOPARTICLES ; FACILE ; AGENT ; NANOMEDICINES ; NANOMATERIALS ; HYPERTHERMIA
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNIH(CA200900 ; Prostate Cancer Foundation Young Investigator Award ; CA160350)
WOS IDWOS:000413166400014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23293
Collection生化工程国家重点实验室
Affiliation1.Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Jilin, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanlan,Ji, Xiaoyuan,Liu, Jianhua,et al. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(39):1703261.
APA Liu, Yanlan,Ji, Xiaoyuan,Liu, Jianhua,Tong, Winnie W. L.,Askhatova, Diana,&Shi, Jinjun.(2017).Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy.ADVANCED FUNCTIONAL MATERIALS,27(39),1703261.
MLA Liu, Yanlan,et al."Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy".ADVANCED FUNCTIONAL MATERIALS 27.39(2017):1703261.
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