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Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer
Ni, Dezhi1; Qing, Shuang1,2; Ding, Hui2; Yue, Hua1; Yu, Di3; Wang, Shuang1,2; Luo, Nana1; Su, Zhiguo1; Wei, Wei1; Ma, Guanghui1,2,4
2017-10-01
发表期刊ADVANCED SCIENCE
ISSN2198-3844
卷号4期号:10
摘要

Failure in enhancing antigen immunogenicity has limited the development of cancer vaccine. Inspired by effective immune responses toward microorganisms, demi-bacteria (DB) from Bacillus are engineered as carriers for cancer vaccines. The explored hydrothermal treatment enables the Bacillus to preserve optimal pathogen morphology with intrinsic mannose receptor agonist. Meanwhile, the treated Bacillus can be further endowed with ideal hollow/porous structure for efficient accommodation of antigen and adjuvant, such as CpG. Therefore, this optimal engineered nanoarchitecture allows multiple immunostimulatory elements integrate in a pattern closely resembling that of bacterial pathogens. Such pathogen mimicry greatly enhances antigen uptake and cross-presentation, resulting in stronger immune activation suitable for cancer vaccines. Indeed, DB-based biomimetic vaccination in mice induces synergistic cellular and humoral immune responses, achieving potent therapeutic and preventive effects against cancer. Application of microorganism-sourced materials thus presents new opportunities for potent cancer therapy.

关键词Bacteria Biomimetic Engineering Cancer Immunotherapy Particulate Adjuvant Vaccines
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/advs.201700083
收录类别SCI
语种英语
关键词[WOS]Advanced Melanoma ; Mannose Receptor ; Dendritic Cells ; Nanoparticles ; Vaccines ; Immunity ; Interleukin-2 ; Immunotherapy ; Phagocytosis ; Autophagy
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Science and Technology Major Projects for
WOS记录号WOS:000413166700004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23301
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Monash Univ, Sch Biomed Sci, Mol Immunomodulat Lab, Clayton, Vic 3800, Australia
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Ni, Dezhi,Qing, Shuang,Ding, Hui,et al. Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer[J]. ADVANCED SCIENCE,2017,4(10).
APA Ni, Dezhi.,Qing, Shuang.,Ding, Hui.,Yue, Hua.,Yu, Di.,...&Ma, Guanghui.(2017).Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer.ADVANCED SCIENCE,4(10).
MLA Ni, Dezhi,et al."Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer".ADVANCED SCIENCE 4.10(2017).
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