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Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer
Ni, Dezhi1; Qing, Shuang1,2; Ding, Hui2; Yue, Hua1; Yu, Di3; Wang, Shuang1,2; Luo, Nana1; Su, Zhiguo1; Wei, Wei1; Ma, Guanghui1,2,4
Source PublicationADVANCED SCIENCE

Failure in enhancing antigen immunogenicity has limited the development of cancer vaccine. Inspired by effective immune responses toward microorganisms, demi-bacteria (DB) from Bacillus are engineered as carriers for cancer vaccines. The explored hydrothermal treatment enables the Bacillus to preserve optimal pathogen morphology with intrinsic mannose receptor agonist. Meanwhile, the treated Bacillus can be further endowed with ideal hollow/porous structure for efficient accommodation of antigen and adjuvant, such as CpG. Therefore, this optimal engineered nanoarchitecture allows multiple immunostimulatory elements integrate in a pattern closely resembling that of bacterial pathogens. Such pathogen mimicry greatly enhances antigen uptake and cross-presentation, resulting in stronger immune activation suitable for cancer vaccines. Indeed, DB-based biomimetic vaccination in mice induces synergistic cellular and humoral immune responses, achieving potent therapeutic and preventive effects against cancer. Application of microorganism-sourced materials thus presents new opportunities for potent cancer therapy.

KeywordBacteria Biomimetic Engineering Cancer Immunotherapy Particulate Adjuvant Vaccines
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
WOS KeywordAdvanced Melanoma ; Mannose Receptor ; Dendritic Cells ; Nanoparticles ; Vaccines ; Immunity ; Interleukin-2 ; Immunotherapy ; Phagocytosis ; Autophagy
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Science and Technology Major Projects for
WOS IDWOS:000413166700004
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Monash Univ, Sch Biomed Sci, Mol Immunomodulat Lab, Clayton, Vic 3800, Australia
4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Ni, Dezhi,Qing, Shuang,Ding, Hui,et al. Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer[J]. ADVANCED SCIENCE,2017,4(10).
APA Ni, Dezhi.,Qing, Shuang.,Ding, Hui.,Yue, Hua.,Yu, Di.,...&Ma, Guanghui.(2017).Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer.ADVANCED SCIENCE,4(10).
MLA Ni, Dezhi,et al."Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer".ADVANCED SCIENCE 4.10(2017).
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