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A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor
Zhang, Yang-xin1,2; Wang, Shao-wei2; Lu, Shuai2; Zhang, Ling-xiao2; Liu, Dong-qun2; Ji, Mei2; Wang, Wei-yun1; Liu, Rui-tian2
2017-11-01
发表期刊FEBS LETTERS
ISSN1873-3468
卷号591期号:21页码:3615-3624
摘要

Beta-amyloid (A beta) oligomers are strongly associated with the cascade of harmful events leading to neurodegeneration in Alzheimer's disease (AD). Elimination of A beta oligomers or inhibition of A beta assembly is a valuable therapeutic approach for the treatment of AD. Here, we obtained a mimotope of A beta oligomers, AOEP2, by screening a peptide library using oligomer-specific antibodies. The antibodies induced by AOEP2 specifically recognize A beta oligomers rather than monomers and fibrils. Interestingly, the AOEP2 peptide binds to A beta monomers and inhibits the formation of A beta oligomers and beta-sheet structure, reduces A beta 42-induced neurotoxicity, and decreases the release of proinflammatory cytokines. Taken together, AOEP2, a novel multifunctional peptide directly or indirectly targeting A beta, has promising therapeutic potential for AD.

关键词Aggregation Beta-amyloid Oligomer Mimotope Peptide Vaccine
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/1873-3468.12871
收录类别SCI
语种英语
关键词[WOS]ALZHEIMERS-DISEASE ; AMYLOID-BETA ; INFLAMMATORY CYTOKINES ; BREAKER PEPTIDES ; NEUROINFLAMMATION ; AUTOANTIBODIES ; FIBRILLATION ; AGGREGATION ; MICE
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
项目资助者National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2012ZX09103301-001 ; 31471720 ; 2014ZX09102045-006) ; 31101335)
WOS记录号WOS:000415051300013
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23378
专题生化工程国家重点实验室
作者单位1.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Anhui, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
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GB/T 7714
Zhang, Yang-xin,Wang, Shao-wei,Lu, Shuai,et al. A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor[J]. FEBS LETTERS,2017,591(21):3615-3624.
APA Zhang, Yang-xin.,Wang, Shao-wei.,Lu, Shuai.,Zhang, Ling-xiao.,Liu, Dong-qun.,...&Liu, Rui-tian.(2017).A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor.FEBS LETTERS,591(21),3615-3624.
MLA Zhang, Yang-xin,et al."A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor".FEBS LETTERS 591.21(2017):3615-3624.
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