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RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review
Qiao, Chenmeng1,2,3; Yang, Jun1; Shen, Qi1,4; Shen, Yan-Qin3; Weng, Jie2; Zhang, Xin1
2017-08-01
发表期刊JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN1550-7033
卷号13期号:8页码:891-910
摘要Glioblastoma is the most common and devastating primary brain tumor in adults. The clinical treatments of glioblastoma are generally focus on surgical excision, chemotherapy and radiotherapy, while the prognosis remains grim. With the adequate understanding of the unique immunological microenvironment in the central nervous system (CNS) and CNS tumors, immune microenvironment modulation becomes a promising treatment modality in glioma. Studies using RNA interference (RNAi) technology to modulate the immune microenvironment are under an active investigation. Using those therapeutic strategies directly or indirectly react with tumor cells, antigen processing cells (APCs, including microglia and dendritic cells (DCs)) and immune cells (such as T cells and natural killer cells (NK cells)) has been extensively studied. Here, we review the current advances in immune microenvironment modulation for glioblastoma with RNAi approach. We also investigate how the factors, associated with immunosuppression, to combat with glioblastoma, and discuss the deficiency for this anti-glioblastoma strategy. From these, we expect to provide a guidance for the future development of RNAi-based immunomodulation strategy for glioblastoma and establish optimized antitumor therapy for clinical treatments.
关键词Rnai-based Immune Modulation The Immunosuppressive Tumor Microenvironment Glioblastoma Immunity Responses Rna Therapeutics
文章类型Review
WOS标题词Science & Technology ; Technology
DOI10.1166/jbn.2017.2388
收录类别SCI
语种英语
关键词[WOS]CENTRAL-NERVOUS-SYSTEM ; BLOOD-BRAIN-BARRIER ; REGULATORY T-CELLS ; GLIOMA-INFILTRATING MICROGLIA/MACROPHAGES ; JUNCTION PROTEIN CONNEXIN43 ; ANTIGEN CROSS-PRESENTATION ; TEMOZOLOMIDE CO-DELIVERY ; GROWTH-FACTOR-RECEPTOR ; DENDRITIC CELLS ; TUMOR MICROENVIRONMENT
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Biomaterials
项目资助者National High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51373177 ; Beijing Municipal Science and Technology Commission(Z161100002616015) ; Beijing Natural Science Foundation(2164071) ; Chinese Academy of Sciences(XDA09030301-3) ; 51573188 ; 31522023)
WOS记录号WOS:000414565900003
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23403
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
3.Jiangnan Univ, Wuxi Med Coll, Wuxi 214122, Peoples R China
4.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
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Qiao, Chenmeng,Yang, Jun,Shen, Qi,et al. RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(8):891-910.
APA Qiao, Chenmeng,Yang, Jun,Shen, Qi,Shen, Yan-Qin,Weng, Jie,&Zhang, Xin.(2017).RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(8),891-910.
MLA Qiao, Chenmeng,et al."RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.8(2017):891-910.
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