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RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review
Qiao, Chenmeng1,2,3; Yang, Jun1; Shen, Qi1,4; Shen, Yan-Qin3; Weng, Jie2; Zhang, Xin1
2017-08-01
Source PublicationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN1550-7033
Volume13Issue:8Pages:891-910
Abstract

Glioblastoma is the most common and devastating primary brain tumor in adults. The clinical treatments of glioblastoma are generally focus on surgical excision, chemotherapy and radiotherapy, while the prognosis remains grim. With the adequate understanding of the unique immunological microenvironment in the central nervous system (CNS) and CNS tumors, immune microenvironment modulation becomes a promising treatment modality in glioma. Studies using RNA interference (RNAi) technology to modulate the immune microenvironment are under an active investigation. Using those therapeutic strategies directly or indirectly react with tumor cells, antigen processing cells (APCs, including microglia and dendritic cells (DCs)) and immune cells (such as T cells and natural killer cells (NK cells)) has been extensively studied. Here, we review the current advances in immune microenvironment modulation for glioblastoma with RNAi approach. We also investigate how the factors, associated with immunosuppression, to combat with glioblastoma, and discuss the deficiency for this anti-glioblastoma strategy. From these, we expect to provide a guidance for the future development of RNAi-based immunomodulation strategy for glioblastoma and establish optimized antitumor therapy for clinical treatments.

KeywordRnai-based Immune Modulation The Immunosuppressive Tumor Microenvironment Glioblastoma Immunity Responses Rna Therapeutics
SubtypeReview
WOS HeadingsScience & Technology ; Technology
DOI10.1166/jbn.2017.2388
Indexed BySCI
Language英语
WOS KeywordCentral-nervous-system ; Blood-brain-barrier ; Regulatory T-cells ; Glioma-infiltrating Microglia/macrophages ; Junction Protein Connexin43 ; Antigen Cross-presentation ; Temozolomide Co-delivery ; Growth-factor-receptor ; Dendritic Cells ; Tumor Microenvironment
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, bioMaterials
Funding OrganizationNational High Technology Research and Development Program(2016YFA0200303) ; National Natural Science Foundation of China(51373177 ; Beijing Municipal Science and Technology Commission(Z161100002616015) ; Beijing Natural Science Foundation(2164071) ; Chinese Academy of Sciences(XDA09030301-3) ; 51573188 ; 31522023)
WOS IDWOS:000414565900003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23403
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Southwest Jiaotong Univ, Key Lab Adv Technol Mat, Minist Educ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China
3.Jiangnan Univ, Wuxi Med Coll, Wuxi 214122, Peoples R China
4.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
Recommended Citation
GB/T 7714
Qiao, Chenmeng,Yang, Jun,Shen, Qi,et al. RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(8):891-910.
APA Qiao, Chenmeng,Yang, Jun,Shen, Qi,Shen, Yan-Qin,Weng, Jie,&Zhang, Xin.(2017).RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(8),891-910.
MLA Qiao, Chenmeng,et al."RNA Interference-Based Immunomodulation for Glioblastoma Immune Microenvironment: A Review".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.8(2017):891-910.
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