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Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids
Wang, Juan1,2; Yuan, Chengqian1,2; Han, Yuchun3; Wang, Yilin3; Liu, Xiaomin2,4; Zhang, Suojiang2,4; Yan, Xuehai1,2
2017-11-27
Source PublicationSMALL
ISSN1613-6810
Volume13Issue:44Pages:1702175
Abstract

The interaction between water and biomolecules including peptides is of critical importance for forming high-level architectures and triggering life's functions. However, the bulk aqueous environment has limitations in detecting the kinetics and mechanisms of peptide self-assembly, especially relating to interactions of trace water. With ionic liquids (ILs) as a nonconventional medium, herein, it is discovered that trace amounts of water play a decisive role in triggering self-assembly of a biologically derived dipeptide. ILs provide a suitable nonaqueous environment, enabling us to mediate water content and follow the dynamic evolution of peptide self-assembly. The trace water is found to be involved in the assembly process of dipeptide, especially leading to the formation of stable noncovalent dipeptide oligomers in the early stage of nucleation, as evident by both experimental studies and theoretical simulations. The thermodynamics of the growth process is mainly governed by a synergistic effect of hydrophobic interaction and hydrogen bonds. Each step of assembly presents a different trend in thermodynamic energy. The dynamic evolution of assembly process can be efficiently mediated by changing trace water content. The decisive role of trace water in triggering and mediating self-assembly of biomolecules provides a new perspective in understanding supramolecular chemistry and molecular self-organization in biology.

KeywordDipeptide Ionic Liquid Kinetics And Thermodynamics Self-assembly Trace Water
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/smll.201702175
Indexed BySCI
Language英语
WOS KeywordTRIPEPTIDE DERIVATIVES ; FIBRIL FORMATION ; PROTEIN ; DIPHENYLALANINE ; BIOMATERIALS ; SPECTROSCOPY ; AGGREGATION ; INTERFACES ; STABILITY ; NANOTUBES
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 91434103)
WOS IDWOS:000416040600008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23432
Collection多相复杂系统国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Juan,Yuan, Chengqian,Han, Yuchun,et al. Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids[J]. SMALL,2017,13(44):1702175.
APA Wang, Juan.,Yuan, Chengqian.,Han, Yuchun.,Wang, Yilin.,Liu, Xiaomin.,...&Yan, Xuehai.(2017).Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids.SMALL,13(44),1702175.
MLA Wang, Juan,et al."Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids".SMALL 13.44(2017):1702175.
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