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Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids
Wang, Juan1,2; Yuan, Chengqian1,2; Han, Yuchun3; Wang, Yilin3; Liu, Xiaomin2,4; Zhang, Suojiang2,4; Yan, Xuehai1,2
2017-11-27
发表期刊SMALL
ISSN1613-6810
卷号13期号:44页码:1702175
摘要

The interaction between water and biomolecules including peptides is of critical importance for forming high-level architectures and triggering life's functions. However, the bulk aqueous environment has limitations in detecting the kinetics and mechanisms of peptide self-assembly, especially relating to interactions of trace water. With ionic liquids (ILs) as a nonconventional medium, herein, it is discovered that trace amounts of water play a decisive role in triggering self-assembly of a biologically derived dipeptide. ILs provide a suitable nonaqueous environment, enabling us to mediate water content and follow the dynamic evolution of peptide self-assembly. The trace water is found to be involved in the assembly process of dipeptide, especially leading to the formation of stable noncovalent dipeptide oligomers in the early stage of nucleation, as evident by both experimental studies and theoretical simulations. The thermodynamics of the growth process is mainly governed by a synergistic effect of hydrophobic interaction and hydrogen bonds. Each step of assembly presents a different trend in thermodynamic energy. The dynamic evolution of assembly process can be efficiently mediated by changing trace water content. The decisive role of trace water in triggering and mediating self-assembly of biomolecules provides a new perspective in understanding supramolecular chemistry and molecular self-organization in biology.

关键词Dipeptide Ionic Liquid Kinetics And Thermodynamics Self-assembly Trace Water
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/smll.201702175
收录类别SCI
语种英语
关键词[WOS]TRIPEPTIDE DERIVATIVES ; FIBRIL FORMATION ; PROTEIN ; DIPHENYLALANINE ; BIOMATERIALS ; SPECTROSCOPY ; AGGREGATION ; INTERFACES ; STABILITY ; NANOTUBES
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 91434103)
WOS记录号WOS:000416040600008
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23432
专题多相复杂系统国家重点实验室
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
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GB/T 7714
Wang, Juan,Yuan, Chengqian,Han, Yuchun,et al. Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids[J]. SMALL,2017,13(44):1702175.
APA Wang, Juan.,Yuan, Chengqian.,Han, Yuchun.,Wang, Yilin.,Liu, Xiaomin.,...&Yan, Xuehai.(2017).Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids.SMALL,13(44),1702175.
MLA Wang, Juan,et al."Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids".SMALL 13.44(2017):1702175.
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