Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield

doi:10.1016/j.foodchem.2017.11.083

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	Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield
	Zhao, Dong 1,2; Xu, Jian 1,3; Xu, Xia 1,3; Xu, X
	2018-04-15
Source Publication	FOOD CHEMISTRY
ISSN	0308-8146
Volume	245 Issue:00 Pages:911-918
Abstract	Due to antitumor and antioxidant activities, there has been increasing interest in fucoidans, sulfated polysaccharides, from brown algae. Currently, the classic hot water extraction and acid extraction are time-consuming, and can cause the partial cleavage of sulfate esters, leading to bioactivity loss. The present study developed a novel process for extracting fucoidans from Laminaria japonica with 0.5% ethylenediaminetetraacetic acid at 70 degrees C. Crude fucoidans (CFs) obtained with a yield (similar to 16%) was purified to different fractions of F1, F2 and F3. The fractions displayed similar anticancer activity against Hela cells. Due to the differences in sulfate content, molar ratio of sulfate to fucose and monosaccharide composition, F1 and F2 exhibited stronger antioxidant ability than CFs and F3. This novel extraction provides an efficient procedure for extracting fucoidans from brown seaweeds with high extraction yield and removing pigments with one single step.
Keyword	Sulfated Polysaccharides Fucoidan Extraction Antioxidant Activity Antitumor Activity Pigments
Subtype	Article
WOS Headings	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI	10.1016/j.foodchem.2017.11.083
Indexed By	SCI
Language	英语
WOS Keyword	Containing Sulfated Polysaccharides ; Microwave-assisted Extraction ; Antioxidant Activity ; Brown Seaweed ; Undaria-pinnatifida ; In-vitro ; Emulsifying Activities ; Potential Antioxidant ; Ascophyllum-nodosum ; Antiviral Activity
WOS Research Area	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS Subject	Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
Funding Organization	National Natural Science Foundation of China(21576266 ; Major Research plan of the National Natural Science Foundation of China(91534107) ; Wanjiang Scholar Program ; Start Fund for Biochemical Engineering Center from Anhui University of Technology ; 21176238)
WOS ID	WOS:000418471100113
Citation statistics	Cited Times:7[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/23448
Collection	研究所（批量导入）
Corresponding Author	Xu, X
Affiliation	1.Anhui Univ Technol, Sch Chem & Chem Engn, Biochem Engn Res Ctr, 59 Hudong St, Maanshan 243032, Anhui, Peoples R China 2.Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation GB/T 7714	Zhao, Dong,Xu, Jian,Xu, Xia,et al. Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield[J]. FOOD CHEMISTRY,2018,245(00):911-918.
APA	Zhao, Dong,Xu, Jian,Xu, Xia,&Xu, X.(2018).Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield.FOOD CHEMISTRY,245(00),911-918.
MLA	Zhao, Dong,et al."Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield".FOOD CHEMISTRY 245.00(2018):911-918.

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