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Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield
Zhao, Dong1,2; Xu, Jian1,3; Xu, Xia1,3; Xu, X
2018-04-15
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume245Issue:00Pages:911-918
Abstract

Due to antitumor and antioxidant activities, there has been increasing interest in fucoidans, sulfated polysaccharides, from brown algae. Currently, the classic hot water extraction and acid extraction are time-consuming, and can cause the partial cleavage of sulfate esters, leading to bioactivity loss. The present study developed a novel process for extracting fucoidans from Laminaria japonica with 0.5% ethylenediaminetetraacetic acid at 70 degrees C. Crude fucoidans (CFs) obtained with a yield (similar to 16%) was purified to different fractions of F1, F2 and F3. The fractions displayed similar anticancer activity against Hela cells. Due to the differences in sulfate content, molar ratio of sulfate to fucose and monosaccharide composition, F1 and F2 exhibited stronger antioxidant ability than CFs and F3. This novel extraction provides an efficient procedure for extracting fucoidans from brown seaweeds with high extraction yield and removing pigments with one single step.

KeywordSulfated Polysaccharides Fucoidan Extraction Antioxidant Activity Antitumor Activity Pigments
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1016/j.foodchem.2017.11.083
Indexed BySCI
Language英语
WOS KeywordContaining Sulfated Polysaccharides ; Microwave-assisted Extraction ; Antioxidant Activity ; Brown Seaweed ; Undaria-pinnatifida ; In-vitro ; Emulsifying Activities ; Potential Antioxidant ; Ascophyllum-nodosum ; Antiviral Activity
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
Funding OrganizationNational Natural Science Foundation of China(21576266 ; Major Research plan of the National Natural Science Foundation of China(91534107) ; Wanjiang Scholar Program ; Start Fund for Biochemical Engineering Center from Anhui University of Technology ; 21176238)
WOS IDWOS:000418471100113
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23448
Collection研究所(批量导入)
Corresponding AuthorXu, X
Affiliation1.Anhui Univ Technol, Sch Chem & Chem Engn, Biochem Engn Res Ctr, 59 Hudong St, Maanshan 243032, Anhui, Peoples R China
2.Beijing Univ Chem Technol, Coll Chem Engn, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Dong,Xu, Jian,Xu, Xia,et al. Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield[J]. FOOD CHEMISTRY,2018,245(00):911-918.
APA Zhao, Dong,Xu, Jian,Xu, Xia,&Xu, X.(2018).Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield.FOOD CHEMISTRY,245(00),911-918.
MLA Zhao, Dong,et al."Bioactivity of fucoidan extracted from Laminaria japonica using a novel procedure with high yield".FOOD CHEMISTRY 245.00(2018):911-918.
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