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Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy
Sun, Haifeng1,2; Li, Shukun2; Qi, Wei1; Xing, Ruirui2; Zou, Qianli2; Yan, Xuehai2
2018-02-05
发表期刊COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
卷号538期号:00页码:795-801
摘要

Nanomaterials constructed by self-assembly of biomolecules are of particular interest as drug delivery carriers in biomedicine. However, supramolecular construction of nanoparticles by self-assembly of highly hydrophilic biomolecules such as hyaluronic acid still remains a formidable challenge due to their water solubility. Herein, we propose a strategy to fabricate stable nanoparticles by self-assembly of hyaluronic acid without the need of modification by hydrophobic groups. This strategy involves the electrostatic assembly of hyaluronic acid and naturally produced epsilon-polylysine and the in situ crosslinking by disulfide bonds. The resulting nanoparticles have the advantages of resistance to dilution, tunable size and surface charge, and efficient encapsulation of Chlorin e6 (Ce6), a photosensitizer for photodynamic therapy (PDT). In addition, the release of Ce6 from the nanoparticles is synergistically responsive to variations of pH and GSH levels. In vitro experiments reveal that the Ce6-loaded nanoparticles exhibit enhanced cellular uptake, improved phototoxicity, and unaltered biocompatibility as compared to unencapsulated Ce6, demonstrating that the nanoparticles constructed by self-assembly of hyaluronic acid are efficient and biocompatible drug delivery carriers for PDT agents.

关键词Polypeptide Hyaluronic Acid Self-assembly Nanodrugs Photodynamic Therapy
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2017.11.072
收录类别SCI
语种英语
关键词[WOS]Hyaluronic-acid ; Drug-delivery ; Enhanced Permeability ; Antitumor Therapy ; Cellular Uptake ; Cancer-therapy ; Ph ; Tumors ; Paclitaxel ; Cells
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 21773248)
WOS记录号WOS:000418586600095
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23451
专题研究所(批量导入)
通讯作者Qi, Wei; Zou, Qianli; Yan, Xuehai
作者单位1.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, 57 Jingxuan West Rd, Qufu 273165, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
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Sun, Haifeng,Li, Shukun,Qi, Wei,et al. Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2018,538(00):795-801.
APA Sun, Haifeng,Li, Shukun,Qi, Wei,Xing, Ruirui,Zou, Qianli,&Yan, Xuehai.(2018).Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,538(00),795-801.
MLA Sun, Haifeng,et al."Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 538.00(2018):795-801.
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