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Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy
Sun, Haifeng1,2; Li, Shukun2; Qi, Wei1; Xing, Ruirui2; Zou, Qianli2; Yan, Xuehai2
2018-02-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume538Issue:00Pages:795-801
Abstract

Nanomaterials constructed by self-assembly of biomolecules are of particular interest as drug delivery carriers in biomedicine. However, supramolecular construction of nanoparticles by self-assembly of highly hydrophilic biomolecules such as hyaluronic acid still remains a formidable challenge due to their water solubility. Herein, we propose a strategy to fabricate stable nanoparticles by self-assembly of hyaluronic acid without the need of modification by hydrophobic groups. This strategy involves the electrostatic assembly of hyaluronic acid and naturally produced epsilon-polylysine and the in situ crosslinking by disulfide bonds. The resulting nanoparticles have the advantages of resistance to dilution, tunable size and surface charge, and efficient encapsulation of Chlorin e6 (Ce6), a photosensitizer for photodynamic therapy (PDT). In addition, the release of Ce6 from the nanoparticles is synergistically responsive to variations of pH and GSH levels. In vitro experiments reveal that the Ce6-loaded nanoparticles exhibit enhanced cellular uptake, improved phototoxicity, and unaltered biocompatibility as compared to unencapsulated Ce6, demonstrating that the nanoparticles constructed by self-assembly of hyaluronic acid are efficient and biocompatible drug delivery carriers for PDT agents.

KeywordPolypeptide Hyaluronic Acid Self-assembly Nanodrugs Photodynamic Therapy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2017.11.072
Indexed BySCI
Language英语
WOS KeywordHyaluronic-acid ; Drug-delivery ; Enhanced Permeability ; Antitumor Therapy ; Cellular Uptake ; Cancer-therapy ; Ph ; Tumors ; Paclitaxel ; Cells
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 21773248)
WOS IDWOS:000418586600095
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23451
Collection研究所(批量导入)
Corresponding AuthorQi, Wei; Zou, Qianli; Yan, Xuehai
Affiliation1.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Pharmaceut Intermediates & Anal Nat Med, Key Lab Life Organ Anal, 57 Jingxuan West Rd, Qufu 273165, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Sun, Haifeng,Li, Shukun,Qi, Wei,et al. Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2018,538(00):795-801.
APA Sun, Haifeng,Li, Shukun,Qi, Wei,Xing, Ruirui,Zou, Qianli,&Yan, Xuehai.(2018).Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,538(00),795-801.
MLA Sun, Haifeng,et al."Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 538.00(2018):795-801.
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