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Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High-Performance Anticancer Therapy
Zhang, Fan1; Zhao, Longjian1; Wang, Shumin1; Yang, Jun1; Lu, Guihong1; Luo, Nana2; Gao, Xiaoyong2; Ma, Guanghui2; Xie, Hai-Yan1; Wei, Wei2
2018-01-04
发表期刊ADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
卷号28期号:1页码:1
摘要

Precisely delivering siRNA to its target site in cancer cells is a high-demanding but challenging task. Herein, a biomimetic magnetosome is developed using magnetic nanocluster (MNC) as the core and Arg-Gly-Asp (RGD) decorated macrophage membrane as the cloak, which is achieved via a combination of MNC synthesis, azide-membrane engineering, electrical assembly, and click chemistry. Such a feature-packed magnetosome enables us to gain the success of high-performance siRNA delivery through superior stealth effect, magnetic resonance imaging, magnetic accumulation, RGD targeting, and favorable cytoplasm trafficking. As a result, target gene expression can be significantly suppressed and tumor growth is effectively inhibited, while the systemic toxicity is not notable. These results together vote the biomimetic magnetosome as a promising siRNA delivery system for anticancer therapy.

关键词Anticancer Therapy Biomimetic Drug Carriers Magnetosomes Sirna Targeting
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201703326
收录类别SCI
语种英语
关键词[WOS]Colloidal Nanocrystal Clusters ; Rna Interference ; Cancer-cells ; Delivery ; Nanoparticles ; Pegylation ; Barriers
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National Natural Science Foundation of China(21372028 ; National Science and Technology Major Project(2014ZX09102045-004) ; National Key R& D Program of China(2017YFA0207901) ; Beijing Talents Fund(2015000021223ZK20) ; 21422502 ; 81571813 ; 81302704 ; 21622608)
WOS记录号WOS:000419025200002
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23464
专题研究所(批量导入)
通讯作者Xie, Hai-Yan; Wei, Wei
作者单位1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
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GB/T 7714
Zhang, Fan,Zhao, Longjian,Wang, Shumin,et al. Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High-Performance Anticancer Therapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(1):1.
APA Zhang, Fan.,Zhao, Longjian.,Wang, Shumin.,Yang, Jun.,Lu, Guihong.,...&Wei, Wei.(2018).Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High-Performance Anticancer Therapy.ADVANCED FUNCTIONAL MATERIALS,28(1),1.
MLA Zhang, Fan,et al."Construction of a Biomimetic Magnetosome and Its Application as a SiRNA Carrier for High-Performance Anticancer Therapy".ADVANCED FUNCTIONAL MATERIALS 28.1(2018):1.
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