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Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes
Zhang, Yue1,2; Yu, Xiao-lin2; Zha, Jun2; Mao, Li-zhen3; Chai, Jia-qian1; Liu, Rui-tian2
2018
发表期刊LIFE SCIENCES
ISSN0024-3205
卷号192期号:00页码:68-74
摘要

Aims: Inflammation is strongly associated with the mechanism of beta-cell failure in type 2 diabetes mellitus (T2DM). Blockade of the key proinflammatory cytokine IL-1 beta has been implicated as a promising therapeutic strategy for the prevention and treatment of type 2 diabetes. In this study, we developed an IL-1 beta-targeted therapeutic vaccine consisting of an IL-1 beta epitope peptide (A1 beta) and assessed its efficacy on a diabetic KK-A(y) mouse model.

关键词Type 2 Diabetes Islet Inflammation Il-1 Beta Therapeutic Vaccine
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.lfs.2017.11.021
收录类别SCI
语种英语
关键词[WOS]Nlrp3 Inflammasome ; Islet Dysfunction ; Mellitus ; Interleukin-1-beta ; Canakinumab ; Antagonist ; Activation ; Management ; Inhibitors ; Antibody
WOS研究方向Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS类目Medicine, Research & Experimental ; Pharmacology & Pharmacy
项目资助者National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12040215) ; Natural Science Foundation of Jiangsu Province of China(BK20140245) ; 81402837) ; 2014ZX09102041-007)
WOS记录号WOS:000418477800010
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23470
专题研究所(批量导入)
通讯作者Chai, Jia-qian; Liu, Rui-tian
作者单位1.Shandong Agr Univ, Shandong Prov Key Lab Anim Biotechnol & Dis Contr, 61 Daizong St, Tai An 271018, Shandong, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Asialand Biomed Technol Co Ltd, Changzhou, Peoples R China
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GB/T 7714
Zhang, Yue,Yu, Xiao-lin,Zha, Jun,et al. Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes[J]. LIFE SCIENCES,2018,192(00):68-74.
APA Zhang, Yue,Yu, Xiao-lin,Zha, Jun,Mao, Li-zhen,Chai, Jia-qian,&Liu, Rui-tian.(2018).Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes.LIFE SCIENCES,192(00),68-74.
MLA Zhang, Yue,et al."Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes".LIFE SCIENCES 192.00(2018):68-74.
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