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Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment
Lu, Zhiguo1,2; Li, Yan1; Shi, Yuanjie1; Li, Yanhui1; Xiao, Zuobing3,4; Zhang, Xin1
2017-12-08
发表期刊ADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
卷号27期号:46页码:1
摘要

Doxorubicin (DOX), one of the most widely used clinical antineoplastics, has ineffective therapeutic efficacy on glioblastoma multiforme (GBM) with extremely short survival time due to many obstacles such as blood-brain barrier (BBB), tumor angiogenesis, and glioblastoma stem cells (GSCs). To overcome, biocompatible nanoparticles named CARD-B6 loading three clinical drugs are developed. Unlike other nanomedicines, CARD-B6, with the ability of spatiotemporally controlled release, maximize the effectiveness of DOX. (1) After CARD-B6 cross the BBB via B6, combretastatin A4 that is first released via protonation of poly (-amino ester) specifically destroys angiogenesis to facilitate the interaction between GBM and CARD-B6. (2) Internalized into glioblastoma cells later, DOX is released via the breakage of amido bond to induce apoptosis, which is facilitated by the simultaneously released all-trans retinoic acid (ATRA). (3) After endocytosis into GSCs, the rapidly released ATRA induces the GSCs differentiation and downregulates the survival pathways, which enhances the sensitivity of GSCs to the subsequently released DOX. This synergistic antitumor effect significantly extends survival time of GBM mouse model. CARD-B6 are traced by superparamagnetic iron oxide nanocubes with high r(2) relaxivity for magnetic resonance imaging. Therefore, the traceable CARD-B6 with spatiotemporally controlled release ability are emerging as a powerful platform for GBM treatment.

关键词Card-b6 Doxorubicin Glioblastoma Multiforme Spatiotemporally Controlled Release Synergistic Treatment
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adfm.201703967
收录类别SCI
语种英语
关键词[WOS]Blood-brain-barrier ; Trans-retinoic Acid ; Cancer Stem-cells ; In-vivo ; U87mg Cells ; Therapy ; Glioma ; Tumors ; Delivery ; Differentiation
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National High Technology Research and Development Program(2016YFA0200303) ; Beijing Natural Science Foundation(2164071) ; National Natural Science Foundation of China(31522023 ; Beijing Municipal Science & Technology Commission(Z161100002616015) ; Chinese Academy of Sciences(XDA09030301-3) ; 51373177 ; 51573188)
WOS记录号WOS:000417187200017
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23485
专题研究所(批量导入)
通讯作者Zhang, Xin
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
3.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
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GB/T 7714
Lu, Zhiguo,Li, Yan,Shi, Yuanjie,et al. Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(46):1.
APA Lu, Zhiguo,Li, Yan,Shi, Yuanjie,Li, Yanhui,Xiao, Zuobing,&Zhang, Xin.(2017).Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment.ADVANCED FUNCTIONAL MATERIALS,27(46),1.
MLA Lu, Zhiguo,et al."Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment".ADVANCED FUNCTIONAL MATERIALS 27.46(2017):1.
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