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Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment
Lu, Zhiguo1,2; Li, Yan1; Shi, Yuanjie1; Li, Yanhui1; Xiao, Zuobing3,4; Zhang, Xin1

Doxorubicin (DOX), one of the most widely used clinical antineoplastics, has ineffective therapeutic efficacy on glioblastoma multiforme (GBM) with extremely short survival time due to many obstacles such as blood-brain barrier (BBB), tumor angiogenesis, and glioblastoma stem cells (GSCs). To overcome, biocompatible nanoparticles named CARD-B6 loading three clinical drugs are developed. Unlike other nanomedicines, CARD-B6, with the ability of spatiotemporally controlled release, maximize the effectiveness of DOX. (1) After CARD-B6 cross the BBB via B6, combretastatin A4 that is first released via protonation of poly (-amino ester) specifically destroys angiogenesis to facilitate the interaction between GBM and CARD-B6. (2) Internalized into glioblastoma cells later, DOX is released via the breakage of amido bond to induce apoptosis, which is facilitated by the simultaneously released all-trans retinoic acid (ATRA). (3) After endocytosis into GSCs, the rapidly released ATRA induces the GSCs differentiation and downregulates the survival pathways, which enhances the sensitivity of GSCs to the subsequently released DOX. This synergistic antitumor effect significantly extends survival time of GBM mouse model. CARD-B6 are traced by superparamagnetic iron oxide nanocubes with high r(2) relaxivity for magnetic resonance imaging. Therefore, the traceable CARD-B6 with spatiotemporally controlled release ability are emerging as a powerful platform for GBM treatment.

KeywordCard-b6 Doxorubicin Glioblastoma Multiforme Spatiotemporally Controlled Release Synergistic Treatment
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
WOS KeywordBlood-brain-barrier ; Trans-retinoic Acid ; Cancer Stem-cells ; In-vivo ; U87mg Cells ; Therapy ; Glioma ; Tumors ; Delivery ; Differentiation
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational High Technology Research and Development Program(2016YFA0200303) ; Beijing Natural Science Foundation(2164071) ; National Natural Science Foundation of China(31522023 ; Beijing Municipal Science & Technology Commission(Z161100002616015) ; Chinese Academy of Sciences(XDA09030301-3) ; 51373177 ; 51573188)
WOS IDWOS:000417187200017
Citation statistics
Document Type期刊论文
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
3.Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
4.Shanghai Res Inst Fragrance & Flavor Ind, Shanghai 200232, Peoples R China
Recommended Citation
GB/T 7714
Lu, Zhiguo,Li, Yan,Shi, Yuanjie,et al. Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(46):1.
APA Lu, Zhiguo,Li, Yan,Shi, Yuanjie,Li, Yanhui,Xiao, Zuobing,&Zhang, Xin.(2017).Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment.ADVANCED FUNCTIONAL MATERIALS,27(46),1.
MLA Lu, Zhiguo,et al."Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for Synergistic Glioblastoma Multiforme Treatment".ADVANCED FUNCTIONAL MATERIALS 27.46(2017):1.
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