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Engineering and delivery of nanocolloids of hydrophobic drugs
Zhao, Luyang1; Shen, Guizhi1,2; Ma, Guanghui1; Yan, Xuehai1,2
2017-11-01
发表期刊ADVANCES IN COLLOID AND INTERFACE SCIENCE
ISSN0001-8686
卷号249期号:00页码:308-320
摘要

A lot of efforts have been devoted to engineering the delivery of hydrophobic drugs due to the high demand of chemotherapy against cancer. While early developed liposomes and polymeric nanoparticles did not meet the requirements of high drug loading efficiency, pure drug nanoparticles appeared to meet these together with high stability. Current drug delivery systems demand an improved performance over the whole aspects of stability, loading capacity, and therapeutic effects. As a result, both new techniques based on traditional methods and totally new procedures are under investigation. In this review, we focus on the evaluation of pure drug nanolloids fabricated by different engineering protocols with emphasis on the size and morphology, delivery and controlled release, and therapeutic effects of these drug nanocolloids.

关键词Nanocolloids Hydrophobic Drugs Delivery And Controlled Release Ostwald Ripening Suppression Nanoengineering
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.cis.2017.04.008
收录类别SCI
语种英语
关键词[WOS]Mesoporous Silica Nanoparticles ; Dipeptide-based Nanocarriers ; Flash Nanoprecipitation ; Photodynamic Therapy ; Cancer-therapy ; Antitumor Therapy ; Pure Nanodrugs ; Carrier-free ; In-vitro ; Stability
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; 21473208 ; 21603233 ; 91434103)
WOS记录号WOS:000418316500020
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23507
专题研究所(批量导入)
通讯作者Yan, Xuehai
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Luyang,Shen, Guizhi,Ma, Guanghui,et al. Engineering and delivery of nanocolloids of hydrophobic drugs[J]. ADVANCES IN COLLOID AND INTERFACE SCIENCE,2017,249(00):308-320.
APA Zhao, Luyang,Shen, Guizhi,Ma, Guanghui,&Yan, Xuehai.(2017).Engineering and delivery of nanocolloids of hydrophobic drugs.ADVANCES IN COLLOID AND INTERFACE SCIENCE,249(00),308-320.
MLA Zhao, Luyang,et al."Engineering and delivery of nanocolloids of hydrophobic drugs".ADVANCES IN COLLOID AND INTERFACE SCIENCE 249.00(2017):308-320.
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