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Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy
Zhang, Qanmei1; Wei, Wei2; Wang, Peilin1; Zuo, Liping1; Li, Feng1; Xu, Jin1; Xi, Xiaobo2; Gao, Xiaoyong2; Ma, Guanghui2; Xie, Hai-Yan1
2017-11-01
发表期刊ACS NANO
ISSN1936-0851
卷号11期号:11页码:10724-10732
摘要

Adoptive T-cell transfer for cancer therapy relies on both effective ex vivo T-cell expansion and in vivo targeting performance. One promising but challenging method for accomplishing this purpose is to construct multifunctional artificial antigen-presenting cells (aAPCs). We herein developed biomimetic magnetosomes as versatile aAPCs, wherein magnetic nanoclusters were coated with azide-engineered leucocyte membranes and then decorated with T-cell stimuli through copper-free click chemistry. These nano aAPCs not only exhibited high performance for antigen-specific cytotoxic T-cell (CTL) expansion and stimulation but also visually and effectively guided reinfused CTLs to tumor tissues through magnetic resonance imaging and magnetic control. The persisting T cells were able to delay tumor growth in a murine lymphoma model, while the systemic toxicity was not notable. These results together demonstrated the excellent potential of this "one-but-all" aAPC platform for T-cell-based anticancer immunotherapy.

关键词Biomimetic Artificial Antigen-presenting Cells Targeting Delivery T-cell Therapy
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.7b04955
收录类别SCI
语种英语
关键词[WOS]Cancer-immunotherapy ; Biological Barriers ; Drug-delivery ; Tumor-cells ; Nanoparticles ; Activation ; Lymphocytes ; Membrane
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China(81571813 ; National Science and Technology Major Projects for
WOS记录号WOS:000416878100014
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23510
专题研究所(批量导入)
通讯作者Xie, Hai-Yan
作者单位1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
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GB/T 7714
Zhang, Qanmei,Wei, Wei,Wang, Peilin,et al. Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy[J]. ACS NANO,2017,11(11):10724-10732.
APA Zhang, Qanmei.,Wei, Wei.,Wang, Peilin.,Zuo, Liping.,Li, Feng.,...&Xie, Hai-Yan.(2017).Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy.ACS NANO,11(11),10724-10732.
MLA Zhang, Qanmei,et al."Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy".ACS NANO 11.11(2017):10724-10732.
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