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One step separation of Aureobasidium pullulans from beta-poly(L-malic acid) fermentation broth by membranes technology
Cui, Jiandong; Li, Hongbao; Luo, Jianquan; Cao, Weifeng; Qiao, Changsheng; Wan, Yinhua
2017
发表期刊JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
ISSN0268-2575
卷号92期号:00页码:845
摘要

BACKGROUND: beta-Poly (L-malic acid) (PMLA) can be used as a pro-drug or for a drug-delivery system, while the separation of PMLA producer cells of Aureobasidium pullulans from its fermentation broth is a challenge. This paper reports the separation of A. pullulans from PMLA fermentation broth by membranes technology. RESULTS: The best separation efficiency was obtained by the membrane with a molecular weight cut off of 300 kDa, an initial feed volume of 1300 mL, a volume reduction ratio (VRR) of 7.2, a cross-flow velocity of 6ms(-1), a trans-membrane pressure (TMP) of 0.2MPa, and a temperature of 40 degrees C. The average flux reached 55.97 Lm(-2) h(-1) with a VRR of 7.2. The main foulingmechanism during the filtration of cell suspension solution was cake layer formation, while it was pore blocking for fermentation broth and cell free broth. Since the cake layer induced by cells would reject some macromolecular substances (i.e. reduce the pore blocking and enhance the fluxes), one step separation of A. pullulans with a 300 kDa membrane was better than that with centrifugation followed by membrane filtration. CONCLUSION: One step separation of A. pullulans by membranes technology would be beneficial for PMLA bio-refinery. (C) 2016 Society of Chemical Industry

关键词Beta-poly(L-malic Acid) Aureobasidium Pullulans Downstream Processing Membranes Technology
文章类型Article
DOI10.1002/jctb.5068
语种英语
WOS记录号WOS:000397404100017
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23527
专题研究所(批量导入)
通讯作者Cao, Weifeng; Wan, Yinhua
推荐引用方式
GB/T 7714
Cui, Jiandong,Li, Hongbao,Luo, Jianquan,et al. One step separation of Aureobasidium pullulans from beta-poly(L-malic acid) fermentation broth by membranes technology[J]. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,2017,92(00):845.
APA Cui, Jiandong,Li, Hongbao,Luo, Jianquan,Cao, Weifeng,Qiao, Changsheng,&Wan, Yinhua.(2017).One step separation of Aureobasidium pullulans from beta-poly(L-malic acid) fermentation broth by membranes technology.JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY,92(00),845.
MLA Cui, Jiandong,et al."One step separation of Aureobasidium pullulans from beta-poly(L-malic acid) fermentation broth by membranes technology".JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 92.00(2017):845.
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