Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components

doi:10.1080/14786419.2017.1292509

CAS OpenIR > 研究所（批量导入）

	Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components
	Liu, Boyan 1,2; Cao, Lili 1; Zhang, Lijun 1,2; Yuan, Xiaofan1 ; Zhao, Bing 1
	2017
发表期刊	NATURAL PRODUCT RESEARCH
ISSN	1478-6419
卷号	31 期号:23 页码:2788-2792
摘要	Eupatorium adenophorum can induce liver toxicity in animals. For the safe utilisation of the weed, the hepatotoxic components need to be discovered. In this study, in vitro hepatotoxicity of different extracts from E. adenophorum were determined on human hepatocyte cell line L02 and hepatocellular carcinoma cell line HepG2. The results showed that water extracts of E. adenophorum exhibited no hepatotoxicity in vitro while high concentrations of the organic solvent extracts had obvious hepatotoxicity. Sesquiterpenes may contribute to the toxicity based on the comparison of composition analysis. Three cadinene sesquiterpenes were purified and identified as 9-oxo-10,11-dehydroageraphorone, 10H alpha-9-oxo-ageraphorone and 10H alpha-9-oxoageraphorone. In vitro hepatotoxic effects of these components were investigated, the IC50 of the three compounds were 122.53, 87.52, and 108.80 mu M in L02 cells and 151.92, 104.48, and 138.08 mu M in HepG2 cells by Cell Counting Kit-8 (CCK-8) assay. The three components were confirmed to be, at least partial, hepatotoxic components.
关键词	Eupatorium Adenophorum Different Solvent Extracts Sesquiterpenes Hepatotoxicity
文章类型	Article
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI	10.1080/14786419.2017.1292509
收录类别	SCI
语种	英语
关键词[WOS]	Polygonum-multiflorum ; Kava Extracts ; In-vitro ; Spreng ; Liver ; Sesquiterpene ; Cytotoxicity ; Constituents ; Toxicity ; Rats
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:000416728300012
引用统计
文献类型	期刊论文
条目标识符	http://ir.ipe.ac.cn/handle/122111/23538
专题	研究所（批量导入）
通讯作者	Yuan, Xiaofan; Zhao, Bing
作者单位	1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Div Biorefinery Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Boyan,Cao, Lili,Zhang, Lijun,et al. Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components[J]. NATURAL PRODUCT RESEARCH,2017,31(23):2788-2792.
APA	Liu, Boyan,Cao, Lili,Zhang, Lijun,Yuan, Xiaofan,&Zhao, Bing.(2017).Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components.NATURAL PRODUCT RESEARCH,31(23),2788-2792.
MLA	Liu, Boyan,et al."Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components".NATURAL PRODUCT RESEARCH 31.23(2017):2788-2792.