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Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components
Liu, Boyan1,2; Cao, Lili1; Zhang, Lijun1,2; Yuan, Xiaofan1; Zhao, Bing1
2017
Source PublicationNATURAL PRODUCT RESEARCH
ISSN1478-6419
Volume31Issue:23Pages:2788-2792
Abstract

Eupatorium adenophorum can induce liver toxicity in animals. For the safe utilisation of the weed, the hepatotoxic components need to be discovered. In this study, in vitro hepatotoxicity of different extracts from E. adenophorum were determined on human hepatocyte cell line L02 and hepatocellular carcinoma cell line HepG2. The results showed that water extracts of E. adenophorum exhibited no hepatotoxicity in vitro while high concentrations of the organic solvent extracts had obvious hepatotoxicity. Sesquiterpenes may contribute to the toxicity based on the comparison of composition analysis. Three cadinene sesquiterpenes were purified and identified as 9-oxo-10,11-dehydroageraphorone, 10H alpha-9-oxo-ageraphorone and 10H alpha-9-oxoageraphorone. In vitro hepatotoxic effects of these components were investigated, the IC50 of the three compounds were 122.53, 87.52, and 108.80 mu M in L02 cells and 151.92, 104.48, and 138.08 mu M in HepG2 cells by Cell Counting Kit-8 (CCK-8) assay. The three components were confirmed to be, at least partial, hepatotoxic components.

KeywordEupatorium Adenophorum Different Solvent Extracts Sesquiterpenes Hepatotoxicity
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1080/14786419.2017.1292509
Indexed BySCI
Language英语
WOS KeywordPolygonum-multiflorum ; Kava Extracts ; In-vitro ; Spreng ; Liver ; Sesquiterpene ; Cytotoxicity ; Constituents ; Toxicity ; Rats
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000416728300012
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23538
Collection研究所(批量导入)
Corresponding AuthorYuan, Xiaofan; Zhao, Bing
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Div Biorefinery Engn, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Boyan,Cao, Lili,Zhang, Lijun,et al. Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components[J]. NATURAL PRODUCT RESEARCH,2017,31(23):2788-2792.
APA Liu, Boyan,Cao, Lili,Zhang, Lijun,Yuan, Xiaofan,&Zhao, Bing.(2017).Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components.NATURAL PRODUCT RESEARCH,31(23),2788-2792.
MLA Liu, Boyan,et al."Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components".NATURAL PRODUCT RESEARCH 31.23(2017):2788-2792.
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