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题名:
Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components
作者: Liu, Boyan1,2; Cao, Lili1; Zhang, Lijun1,2; Yuan, Xiaofan1; Zhao, Bing1
刊名: NATURAL PRODUCT RESEARCH
出版日期: 2017
卷号: 31, 期号:23, 页码:2788-2792
关键词: Eupatorium adenophorum ; different solvent extracts ; sesquiterpenes ; hepatotoxicity
收录类别: SCI
WOS记录号: WOS:000416728300012
DOI: 10.1080/14786419.2017.1292509
通讯作者: Yuan, XF ; Zhao, B (reprint author), Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Div Biorefinery Engn, Beijing, Peoples R China.
文章类型: Article
英文摘要: Eupatorium adenophorum can induce liver toxicity in animals. For the safe utilisation of the weed, the hepatotoxic components need to be discovered. In this study, in vitro hepatotoxicity of different extracts from E. adenophorum were determined on human hepatocyte cell line L02 and hepatocellular carcinoma cell line HepG2. The results showed that water extracts of E. adenophorum exhibited no hepatotoxicity in vitro while high concentrations of the organic solvent extracts had obvious hepatotoxicity. Sesquiterpenes may contribute to the toxicity based on the comparison of composition analysis. Three cadinene sesquiterpenes were purified and identified as 9-oxo-10,11-dehydroageraphorone, 10H alpha-9-oxo-ageraphorone and 10H alpha-9-oxoageraphorone. In vitro hepatotoxic effects of these components were investigated, the IC50 of the three compounds were 122.53, 87.52, and 108.80 mu M in L02 cells and 151.92, 104.48, and 138.08 mu M in HepG2 cells by Cell Counting Kit-8 (CCK-8) assay. The three components were confirmed to be, at least partial, hepatotoxic components.
WOS标题词: Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
类目[WOS]: Chemistry, Applied ; Chemistry, Medicinal
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: POLYGONUM-MULTIFLORUM ; KAVA EXTRACTS ; IN-VITRO ; SPRENG ; LIVER ; SESQUITERPENE ; CYTOTOXICITY ; CONSTITUENTS ; TOXICITY ; RATS
语种: 英语
ISSN号: 1478-6419
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内容类型: 期刊论文
URI标识: http://ir.ipe.ac.cn/handle/122111/23538
Appears in Collections:研究所(批量导入)_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Div Biorefinery Engn, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Liu, Boyan,Cao, Lili,Zhang, Lijun,et al. Hepatotoxicity of Eupatorium adenophorum extracts and the identification of major hepatotoxic components[J]. NATURAL PRODUCT RESEARCH,2017,31(23):2788-2792.
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