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Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy
Liu, Yanlan1,2,3; Ji, Xiaoyuan1,2; Tong, Winnie W. L.1,2; Askhatova, Diana1,2; Yang, Tingyuan1,2,5; Cheng, Hongwei4; Wang, Yuzhuo4; Shi, Jinjun1,2
2018-02-05
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:6Pages:1510-1513
Abstract

Cancer hallmarks allow the complexity and heterogeneity of tumor biology to be better understood, leading to the discovery of various promising targets for cancer therapy. An amorphous iron oxide nanoparticle (NP)-based RNAi strategy is developed to co-target two cancer hallmarks. The NP technology can modulate the glycolysis pathway by silencing MCT4 to induce tumor cell acidosis, and concurrently exacerbate oxidative stress in tumor cells via the Fenton-like reaction. This strategy has the following features for systemic siRNA delivery: 1)siRNA encapsulation within NPs for improving systemic stability; 2)effective endosomal escape through osmotic pressure and/or endosomal membrane oxidation; 3)small size for enhancing tumor tissue penetration; and 4)triple functions (RNAi, Fenton-like reaction, and MRI) for combinatorial therapy and invivo tracking.

KeywordCancer Hallmarks Iron Oxide Nanoparticles Mri Rnai Tumor Penetration
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/anie.201710144
Indexed BySCI
Language英语
WOS KeywordSystemic Sirna Delivery ; Lipid Nanoparticles ; Prostate-cancer ; Iron ; Hypoxia ; Therapeutics ; Metabolism ; Activation ; Tumor ; Cell
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNIH/NCI(R01CA200900) ; Prostate Cancer Foundation Young Investigator Award
WOS IDWOS:000423494500011
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23980
Collection生化工程国家重点实验室
Affiliation1.Harvard Med Sch, Ctr Nanomed, Boston, MA 02115 USA
2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
3.Hunan Univ, Mol Sci & Biomedicine Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
4.British Columbia Canc Agcy, Dept Expt Therapeut, Vancouver, BC V5Z 1L3, Canada
5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanlan,Ji, Xiaoyuan,Tong, Winnie W. L.,et al. Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(6):1510-1513.
APA Liu, Yanlan.,Ji, Xiaoyuan.,Tong, Winnie W. L..,Askhatova, Diana.,Yang, Tingyuan.,...&Shi, Jinjun.(2018).Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(6),1510-1513.
MLA Liu, Yanlan,et al."Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.6(2018):1510-1513.
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