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Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy
Liu, Yanlan1,2,3; Ji, Xiaoyuan1,2; Tong, Winnie W. L.1,2; Askhatova, Diana1,2; Yang, Tingyuan1,2,5; Cheng, Hongwei4; Wang, Yuzhuo4; Shi, Jinjun1,2
2018-02-05
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号57期号:6页码:1510-1513
摘要Cancer hallmarks allow the complexity and heterogeneity of tumor biology to be better understood, leading to the discovery of various promising targets for cancer therapy. An amorphous iron oxide nanoparticle (NP)-based RNAi strategy is developed to co-target two cancer hallmarks. The NP technology can modulate the glycolysis pathway by silencing MCT4 to induce tumor cell acidosis, and concurrently exacerbate oxidative stress in tumor cells via the Fenton-like reaction. This strategy has the following features for systemic siRNA delivery: 1)siRNA encapsulation within NPs for improving systemic stability; 2)effective endosomal escape through osmotic pressure and/or endosomal membrane oxidation; 3)small size for enhancing tumor tissue penetration; and 4)triple functions (RNAi, Fenton-like reaction, and MRI) for combinatorial therapy and invivo tracking.
关键词Cancer Hallmarks Iron Oxide Nanoparticles Mri Rnai Tumor Penetration
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1002/anie.201710144
收录类别SCI
语种英语
关键词[WOS]SYSTEMIC SIRNA DELIVERY ; LIPID NANOPARTICLES ; PROSTATE-CANCER ; IRON ; HYPOXIA ; THERAPEUTICS ; METABOLISM ; ACTIVATION ; TUMOR ; CELL
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
项目资助者NIH/NCI(R01CA200900) ; Prostate Cancer Foundation Young Investigator Award
WOS记录号WOS:000423494500011
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/23980
专题生化工程国家重点实验室
作者单位1.Harvard Med Sch, Ctr Nanomed, Boston, MA 02115 USA
2.Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
3.Hunan Univ, Mol Sci & Biomedicine Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
4.British Columbia Canc Agcy, Dept Expt Therapeut, Vancouver, BC V5Z 1L3, Canada
5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
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Liu, Yanlan,Ji, Xiaoyuan,Tong, Winnie W. L.,et al. Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(6):1510-1513.
APA Liu, Yanlan.,Ji, Xiaoyuan.,Tong, Winnie W. L..,Askhatova, Diana.,Yang, Tingyuan.,...&Shi, Jinjun.(2018).Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(6),1510-1513.
MLA Liu, Yanlan,et al."Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.6(2018):1510-1513.
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