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Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix
Xing, Ruirui1; Yuan, Chengqian1,2; Li, Shukun1,4; Song, Jingwen1; Li, Junbai3; Yan, Xuehai1,2,4
2018-02-05
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:6Pages:1537-1542
AbstractSecondary structures such as alpha-helix and beta-sheet are the major structural motifs within the three-dimensional geometry of proteins. Therefore, structure transitions from beta-sheet to alpha-helix not only can serve as an effective strategy for the therapy of neurological diseases through the inhibition of -sheet aggregation but also extend the application of alpha-helix fibrils in biomedicine. Herein, we present a charge-induced secondary structure transition of amyloid-derived dipeptide assemblies from beta-sheet to alpha-helix. We unravel that the electrostatic (charge) repulsion between the C-terminal charges of the dipeptide molecules are responsible for the conversion of the secondary structure. This finding provides a new perspective to understanding the secondary structure formation and transformation in the supramolecular organization and life activity.
KeywordGels Nanofibers Peptides Phase Transitions Self-assembly
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/anie.201710642
Indexed BySCI
Language英语
WOS KeywordSUPRAMOLECULAR HYDROGELS ; INFRARED-SPECTROSCOPY ; PEPTIDE AMPHIPHILES ; PROTEIN-STRUCTURE ; SELF-ASSEMBLES ; ARCHITECTURE ; TEMPERATURE ; SOLVENT ; SWITCH
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; CAS President's International Fellowship Initiative(2017DE0004 ; 21473208 ; 2017VEA0023) ; 91434103)
WOS IDWOS:000423494500017
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/23986
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xing, Ruirui,Yuan, Chengqian,Li, Shukun,et al. Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(6):1537-1542.
APA Xing, Ruirui,Yuan, Chengqian,Li, Shukun,Song, Jingwen,Li, Junbai,&Yan, Xuehai.(2018).Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(6),1537-1542.
MLA Xing, Ruirui,et al."Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.6(2018):1537-1542.
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