CAS OpenIR  > 生化工程国家重点实验室
Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation
Zheng, Junping1,2,3,4; Jiao, Siming3,4; Li, Qiongyu3,4; Jia, Peiyuan3,4; Yin, Heng1; Zhao, Xiaoming1; Du, Yuguang3,4; Liu, Hongtao3,4,5
2018
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:1
Abstract

Antrodia cinnamomea (AC), an edible fungus growing in Taiwan, has various health benefits. This study was designed to examine the potential inhibitory effects of AC oligosaccharides on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. By trifluoroacetic acid degradation, two oligosaccharide products were prepared from AC polysaccharides at 90 degrees C (ACHO) or 25 degrees C (ACCO), which showed different oligosaccharide identities. Compared to ACCO, ACHO displayed better inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1, TNF- and MCP-1 in macrophage cells. Further, ACHO significantly suppressed the inflammation in lung tissues of LPS-injected C57BL/6 mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation. Our results suggest that the suppressive effect of AC oligosaccharides on inflammation may be an effective approach for the prevention of inflammation-related diseases.

KeywordAntrodia Cinnamomea Akt Inflammation O-glcnacylation Oligosaccharides
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.3390/molecules23010051
Indexed BySCI
Language英语
WOS KeywordBeta-n-acetylglucosamine ; Lps-induced Inflammation ; Kappa-b ; Camphorata Mycelia ; Medicinal Mushroom ; Polysaccharides ; Glcnac ; Cells ; Modulation ; Activation
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(31500747 ; National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; 31570801)
WOS IDWOS:000425082500048
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/24029
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Liaoning Prov Key Lab Carbohydrates, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, State Key Lab Biochem Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China
Recommended Citation
GB/T 7714
Zheng, Junping,Jiao, Siming,Li, Qiongyu,et al. Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation[J]. MOLECULES,2018,23(1).
APA Zheng, Junping.,Jiao, Siming.,Li, Qiongyu.,Jia, Peiyuan.,Yin, Heng.,...&Liu, Hongtao.(2018).Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.MOLECULES,23(1).
MLA Zheng, Junping,et al."Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation".MOLECULES 23.1(2018).
Files in This Item:
File Name/Size DocType Version Access License
Antrodia cinnamomea (18140KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zheng, Junping]'s Articles
[Jiao, Siming]'s Articles
[Li, Qiongyu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zheng, Junping]'s Articles
[Jiao, Siming]'s Articles
[Li, Qiongyu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zheng, Junping]'s Articles
[Jiao, Siming]'s Articles
[Li, Qiongyu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.