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Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation
Zheng, Junping1,2,3,4; Jiao, Siming3,4; Li, Qiongyu3,4; Jia, Peiyuan3,4; Yin, Heng1; Zhao, Xiaoming1; Du, Yuguang3,4; Liu, Hongtao3,4,5
2018
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:1
摘要Antrodia cinnamomea (AC), an edible fungus growing in Taiwan, has various health benefits. This study was designed to examine the potential inhibitory effects of AC oligosaccharides on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. By trifluoroacetic acid degradation, two oligosaccharide products were prepared from AC polysaccharides at 90 degrees C (ACHO) or 25 degrees C (ACCO), which showed different oligosaccharide identities. Compared to ACCO, ACHO displayed better inhibitory effects on LPS-induced mRNA expression of pro-inflammatory cytokines including IL-6, IL-8, IL-1, TNF- and MCP-1 in macrophage cells. Further, ACHO significantly suppressed the inflammation in lung tissues of LPS-injected C57BL/6 mice. The potential anti-inflammatory molecular mechanism may be associated with the promotion of protein O-GlcNAcylation, which further skewed toward the marked suppression of p38 and Akt phosphorylation. Our results suggest that the suppressive effect of AC oligosaccharides on inflammation may be an effective approach for the prevention of inflammation-related diseases.
关键词Antrodia Cinnamomea Akt Inflammation O-glcnacylation Oligosaccharides
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.3390/molecules23010051
收录类别SCI
语种英语
关键词[WOS]BETA-N-ACETYLGLUCOSAMINE ; LPS-INDUCED INFLAMMATION ; KAPPA-B ; CAMPHORATA MYCELIA ; MEDICINAL MUSHROOM ; POLYSACCHARIDES ; GLCNAC ; CELLS ; MODULATION ; ACTIVATION
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
项目资助者National Natural Science Foundation of China(31500747 ; National Programs for High Technology Research and Development (863 Programs)(2014AA093604) ; 31570801)
WOS记录号WOS:000425082500048
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24029
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Liaoning Prov Key Lab Carbohydrates, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, State Key Lab Biochem Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China
5.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China
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Zheng, Junping,Jiao, Siming,Li, Qiongyu,et al. Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation[J]. MOLECULES,2018,23(1).
APA Zheng, Junping.,Jiao, Siming.,Li, Qiongyu.,Jia, Peiyuan.,Yin, Heng.,...&Liu, Hongtao.(2018).Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation.MOLECULES,23(1).
MLA Zheng, Junping,et al."Antrodia cinnamomea Oligosaccharides Suppress Lipopolysaccharide-Induced Inflammation through Promoting O-GlcNAcylation and Repressing p38/Akt Phosphorylation".MOLECULES 23.1(2018).
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