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Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents
Zhang, Yongqiang1,2; Prawang, Phongphat1; Li, Chunshan1,2; Meng, Xiangzhan1; Zhao, Yu3; Wang, Hui1; Zhang, Suojiang1
2018-02-07
发表期刊GREEN CHEMISTRY
ISSN1463-9262
卷号20期号:3页码:713-723
摘要Artemisinin is a kind of natural antimalarial drug exhibiting low toxicity and a very fast action against malaria. Solvent extraction is the most widely used method to separate artemisinin from the Chinese medicinal herb Artemisia annua L. In this study, a series of monoether-based solvents were investigated to extract artemisinin, and propylene glycol methyl ether (PGME) was found to be the most appropriate one for this extraction. Ultrasonic irradiation was demonstrated to be able to assist artemisinin extraction. Influence of extraction conditions, including liquid/solid ratio, extraction temperature, ultrasonic time, and ultrasonic power, on the extraction efficiency were discussed by single-factor experiments, and the main influencing factors were optimized by response surface methods. The extraction mechanism was explored using spectroscopic characterizations, and kinetics of this process was also studied. Results indicated that ultrasonic assisted extraction using PGME had faster extraction rate than conventional solvents, and ultrasonic could significantly enhance mass transfer. Compared with conventional extraction, the process developed here exhibited a higher efficiency (13.79 mg g(-1) vs. 13.29 mg g(-1)) and shorter extraction time (decreased from 8 h to 0.5 h) at a relatively low temperature. In addition, PGME had low toxicity and volatility, making the extraction process more safe and reliable. Therefore, this proposed method demonstrated that PGME-based ultrasonic assisted extraction is a rapid, efficient, simple and safe technique for natural product extraction.
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c7gc03191b
收录类别SCI
语种英语
关键词[WOS]LIQUID-LIQUID MICROEXTRACTION ; SUPERCRITICAL CARBON-DIOXIDE ; CENTRAL COMPOSITE DESIGN ; IONIC LIQUIDS ; ANTIOXIDANT CAPACITY ; GREEN EXTRACTION ; ESSENTIAL OIL ; QING-HAO ; OPTIMIZATION ; TOXICITY
WOS研究方向Chemistry ; Science & Technology - Other Topics
WOS类目Chemistry, Multidisciplinary ; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY
项目资助者Hundred Talents Program of Chinese Academy of Sciences ; National Basic Research Program of China (973 Program)(2015CB251401) ; International Cooperation and Exchange of the National Natural Science Foundation of China(51561145020) ; CAS/SAFEA International Partnership Program for Creative Research Teams(20140491518) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-JSC011)
WOS记录号WOS:000424276300020
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24037
专题多相复杂系统国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, CAS Key Lab Green Proc Engn,Beijing Key Lab Ion L, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Chem Engn & Energy, Zhengzhou 450001, Henan, Peoples R China
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GB/T 7714
Zhang, Yongqiang,Prawang, Phongphat,Li, Chunshan,et al. Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents[J]. GREEN CHEMISTRY,2018,20(3):713-723.
APA Zhang, Yongqiang.,Prawang, Phongphat.,Li, Chunshan.,Meng, Xiangzhan.,Zhao, Yu.,...&Zhang, Suojiang.(2018).Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents.GREEN CHEMISTRY,20(3),713-723.
MLA Zhang, Yongqiang,et al."Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents".GREEN CHEMISTRY 20.3(2018):713-723.
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