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Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents
Zhang, Yongqiang1,2; Prawang, Phongphat1; Li, Chunshan1,2; Meng, Xiangzhan1; Zhao, Yu3; Wang, Hui1; Zhang, Suojiang1
Source PublicationGREEN CHEMISTRY

Artemisinin is a kind of natural antimalarial drug exhibiting low toxicity and a very fast action against malaria. Solvent extraction is the most widely used method to separate artemisinin from the Chinese medicinal herb Artemisia annua L. In this study, a series of monoether-based solvents were investigated to extract artemisinin, and propylene glycol methyl ether (PGME) was found to be the most appropriate one for this extraction. Ultrasonic irradiation was demonstrated to be able to assist artemisinin extraction. Influence of extraction conditions, including liquid/solid ratio, extraction temperature, ultrasonic time, and ultrasonic power, on the extraction efficiency were discussed by single-factor experiments, and the main influencing factors were optimized by response surface methods. The extraction mechanism was explored using spectroscopic characterizations, and kinetics of this process was also studied. Results indicated that ultrasonic assisted extraction using PGME had faster extraction rate than conventional solvents, and ultrasonic could significantly enhance mass transfer. Compared with conventional extraction, the process developed here exhibited a higher efficiency (13.79 mg g(-1) vs. 13.29 mg g(-1)) and shorter extraction time (decreased from 8 h to 0.5 h) at a relatively low temperature. In addition, PGME had low toxicity and volatility, making the extraction process more safe and reliable. Therefore, this proposed method demonstrated that PGME-based ultrasonic assisted extraction is a rapid, efficient, simple and safe technique for natural product extraction.

WOS HeadingsScience & Technology ; Physical Sciences
Indexed BySCI
WOS KeywordLiquid-liquid Microextraction ; Supercritical Carbon-dioxide ; Central Composite Design ; Ionic Liquids ; Antioxidant Capacity ; Green Extraction ; Essential Oil ; Qing-hao ; Optimization ; Toxicity
WOS Research AreaChemistry ; Science & Technology - Other Topics
WOS SubjectChemistry, Multidisciplinary ; Green & Sustainable Science & Technology
Funding OrganizationHundred Talents Program of Chinese Academy of Sciences ; National Basic Research Program of China (973 Program)(2015CB251401) ; International Cooperation and Exchange of the National Natural Science Foundation of China(51561145020) ; CAS/SAFEA International Partnership Program for Creative Research Teams(20140491518) ; Key Research Program of Frontier Sciences, CAS(QYZDY-SSW-JSC011)
WOS IDWOS:000424276300020
Citation statistics
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, CAS Key Lab Green Proc Engn,Beijing Key Lab Ion L, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Chem Engn & Energy, Zhengzhou 450001, Henan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yongqiang,Prawang, Phongphat,Li, Chunshan,et al. Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents[J]. GREEN CHEMISTRY,2018,20(3):713-723.
APA Zhang, Yongqiang.,Prawang, Phongphat.,Li, Chunshan.,Meng, Xiangzhan.,Zhao, Yu.,...&Zhang, Suojiang.(2018).Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents.GREEN CHEMISTRY,20(3),713-723.
MLA Zhang, Yongqiang,et al."Ultrasonic assisted extraction of artemisinin from Artemisia Annua L. using monoether-based solvents".GREEN CHEMISTRY 20.3(2018):713-723.
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