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Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification
Na, Xiangming1,2; Zhou, Weiqing1; Li, Juan1; Su, Zhiguo1; Ma, Guanghui1
2018
发表期刊PROGRESS IN CHEMISTRY
ISSN1005-281X
卷号30期号:1页码:5-13
摘要Porous polymer microspheres have been widely used in separation and purification of drugs, which are a series of important biochemical engineering products. Formation of porous microspheres is a complex process. Microspheres with pore size below 100 nm is obtained by phase separation of polymers and porogens, while microspheres with pore size above 100 nm can be obtained by phase separation of polymers and water. The porous microspheres with different structures should be delicately designed to meet the application needs. Suspension and seeded polymerizations methods which can be used to fabricate macro-, meso- and nanoporous microspheres are reviewed. Besides, reverse micelles swelling and double emulsion methods are introduced in detail to prepare gigaporous microspheres based on our group 's research. HB-VLPs are used to prove the advantages of gigaporous microspheres in biomacromolecules purification by comparison with mesoporous microspheres.
关键词Porous Microspheres Gigaporous Microspheres Virus-like Particles (Vlps) Separation And Purification Of Biomacromolecules
文章类型Review
WOS标题词Science & Technology ; Physical Sciences
DOI10.7536/PC170922
收录类别SCI
语种英语
关键词[WOS]MICELLES SWELLING METHOD ; MEDIA
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
项目资助者National Natural Science Foundation of China(21336010 ; 21476241)
WOS记录号WOS:000425931300002
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/24038
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Na, Xiangming,Zhou, Weiqing,Li, Juan,et al. Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification[J]. PROGRESS IN CHEMISTRY,2018,30(1):5-13.
APA Na, Xiangming,Zhou, Weiqing,Li, Juan,Su, Zhiguo,&Ma, Guanghui.(2018).Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification.PROGRESS IN CHEMISTRY,30(1),5-13.
MLA Na, Xiangming,et al."Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification".PROGRESS IN CHEMISTRY 30.1(2018):5-13.
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