| Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification | |
| Na, Xiangming1,2; Zhou, Weiqing1; Li, Juan1; Su, Zhiguo1; Ma, Guanghui1 | |
| 2018 | |
| Source Publication | PROGRESS IN CHEMISTRY
 |
| ISSN | 1005-281X |
| Volume | 30Issue:1Pages:5-13 |
| Abstract | Porous polymer microspheres have been widely used in separation and purification of drugs, which are a series of important biochemical engineering products. Formation of porous microspheres is a complex process. Microspheres with pore size below 100 nm is obtained by phase separation of polymers and porogens, while microspheres with pore size above 100 nm can be obtained by phase separation of polymers and water. The porous microspheres with different structures should be delicately designed to meet the application needs. Suspension and seeded polymerizations methods which can be used to fabricate macro-, meso- and nanoporous microspheres are reviewed. Besides, reverse micelles swelling and double emulsion methods are introduced in detail to prepare gigaporous microspheres based on our group 's research. HB-VLPs are used to prove the advantages of gigaporous microspheres in biomacromolecules purification by comparison with mesoporous microspheres. |
| Keyword | Porous Microspheres Gigaporous Microspheres Virus-like Particles (Vlps) Separation And Purification Of Biomacromolecules |
| Subtype | Review |
| WOS Headings | Science & Technology ; Physical Sciences |
| DOI | 10.7536/PC170922 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | MICELLES SWELLING METHOD ; MEDIA |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China(21336010 ; 21476241) |
| WOS ID | WOS:000425931300002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/24038 |
| Collection | 生化工程国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Na, Xiangming,Zhou, Weiqing,Li, Juan,et al. Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification[J]. PROGRESS IN CHEMISTRY,2018,30(1):5-13. |
| APA | Na, Xiangming,Zhou, Weiqing,Li, Juan,Su, Zhiguo,&Ma, Guanghui.(2018).Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification.PROGRESS IN CHEMISTRY,30(1),5-13. |
| MLA | Na, Xiangming,et al."Preparation and Application of Porous Polymer Microspheres in Virus-Like Particles Purification".PROGRESS IN CHEMISTRY 30.1(2018):5-13. |
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